LAB: a new membrane-associated adaptor molecule in B cell activation.
The adaptor molecule, linker for activation of T cells (LAT), is essential in T cell activation and development; a similar molecule in B cells has not yet been identified. Here, we report the identification of a new adaptor protein, linker for activation of B cells (LAB). Like LAT, LAB was ... localized to lipid rafts. Upon activation via the B cell receptor (BCR), LAB was phosphorylated and interacted with the adaptor protein Grb2. Decreased LAB expression led to a reduction in BCR-mediated calcium flux and Erk activation. LAB rescued thymocyte development but not normal T cell activation in LAT(-/-) mice. Our data suggest that LAB links BCR engagement to downstream signaling pathways.
Mesh Terms:
Adaptor Proteins, Signal Transducing, Adaptor Proteins, Vesicular Transport, Amino Acid Sequence, Animals, B-Lymphocytes, Carrier Proteins, Cloning, Molecular, Humans, Lymphocyte Activation, Membrane Proteins, Mice, Mice, Inbred C57BL, Mice, Knockout, Molecular Sequence Data, Phosphoproteins, Phosphorylation, Proteins, RNA, Messenger, Sequence Homology, Amino Acid, Signal Transduction, Tissue Distribution, Tyrosine
Adaptor Proteins, Signal Transducing, Adaptor Proteins, Vesicular Transport, Amino Acid Sequence, Animals, B-Lymphocytes, Carrier Proteins, Cloning, Molecular, Humans, Lymphocyte Activation, Membrane Proteins, Mice, Mice, Inbred C57BL, Mice, Knockout, Molecular Sequence Data, Phosphoproteins, Phosphorylation, Proteins, RNA, Messenger, Sequence Homology, Amino Acid, Signal Transduction, Tissue Distribution, Tyrosine
Nat. Immunol.
Date: Feb. 01, 2003
PubMed ID: 12514734
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