antibody

Bivalent ligand 399

Synonyms/Brands: AC-1, Bivalent_ligand_399
Bivalent ligands are compounds that bridge two protein partners to form a ternary complex, resulting in ubiquitin-proteasome mediated degradation, lysosomal degradation or other means of target protein inactivation. Applies to PROTACs and other heterobifunctional compounds in which two distinct protein binding moieties are connected with a linker, as well as single entity molecular glue compounds that contact both proteins without a linker.
METHOD:: AbTAC (Antibody-based PROTACs, in which bispecific IgGs bind to two proteins simultaneously, an E3 and POI; target degraded via UPS)
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10152
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