small molecule

Bivalent ligand 434

Synonyms/Brands: VHL-12VC1.2 fusion, Bivalent_ligand_434
Bivalent ligands are compounds that bridge two protein partners to form a ternary complex, resulting in ubiquitin-proteasome mediated degradation, lysosomal degradation or other means of target protein inactivation. Applies to PROTACs and other heterobifunctional compounds in which two distinct protein binding moieties are connected with a linker, as well as single entity molecular glue compounds that contact both proteins without a linker.
METHOD:: bioPROTAC (Engineered intracellular proteins consisting of a target-binding domain directly fused to an E3 ubiquitin ligase)
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