Bivalent ligands are compounds that bridge two protein partners to form a ternary complex, resulting in ubiquitin-proteasome mediated degradation, lysosomal degradation or other means of target protein inactivation. Applies to PROTACs and other heterobifunctional compounds in which two distinct protein binding moieties are connected with a linker, as well as single entity molecular glue compounds that contact both proteins without a linker.