small molecule

Tetrahydrofolic acid

Synonyms/Brands: THF, (6S)-THFA, tetrahydrofolate, Tetrahydrofolic acid, (6S)-Tetrahydrofolate, 5,6,7,8-tetrahydrofolate, (6S)-Tetrahydrofolic acid, 5,6,7,8-tetrahydrofolic acid

Tetrahydrofolic acid is a folic acid derivative. It is produced from dihydrofolic acid by dihydrofolate reductase.It is converted into 5,10-methylenetetrahydrofolate by serine hydroxymethyltransferase. It is a coenzyme in many reactions, especially in the metabolism of amino acids and nucleic acids. It acts as a donor of a group with one carbon atom. It gets this carbon atom by sequestering formaldehyde produced in other processes.

Molecular Formula: C₁₉H₂₃N₇O₆

Molecular Weight:: 445.4292

CAS:: 135-16-0

InChiKey:: MSTNYGQPCMXVAQ-KIYNQFGBSA-N

InChi:: InChI=1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t11?,12-/m0/s1

SMILES:: NC1=NC(=O)C2=C(NCC(CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)N2)N1

IUPAC Name:: (2S)-2-[(4-{[(2-amino-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid

DrugBank PubChem ChemSpider ChEBI PDB

Download Curated Data for this Chemical

111

Interactors 11
Chemical Interactions 51
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Chemical Summary

Tetrahydrofolic acid