small molecule

Budesonide

Synonyms/Brands: u, pulmicort nebuamp 0.25 mg/ml, (11beta,16alpha)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione

Budesonide is a glucocorticoid used in the management of asthma, the treatment of various skin disorders, and allergic rhinitis. The extended release oral tablet, marketed as Uceris, was FDA approved on January 14, 2013 for the management of ulcerative colitis. Budesonide is provided as a mixture of two epimers (22R and 22S). Interestingly, the 22R form is two times more active than the 22S epimer. The two forms do not interconvert.

Molecular Formula: C₂₅H₃₄O₆

Molecular Weight:: 430.5339

CAS:: 51333-22-3

ATC:: R03AK12, A07EA06, R03AK07, R03BA02, D07AC09, R01AD05

InChiKey:: VOVIALXJUBGFJZ-KWVAZRHASA-N

InChi:: InChI=1S/C25H34O6/c1-4-5-21-30-20-11-17-16-7-6-14-10-15(27)8-9-23(14,2)22(16)18(28)12-24(17,3)25(20,31-21)19(29)13-26/h8-10,16-18,20-22,26,28H,4-7,11-13H2,1-3H3/t16-,17-,18-,20+,21?,22+,23-,24-,25+/m0/s1

SMILES:: [H][C@@]12C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)C=C[C@]12C

IUPAC Name:: (1S,2S,4R,8S,9S,11S,12S,13R)-11-hydroxy-8-(2-hydroxyacetyl)-9,13-dimethyl-6-propyl-5,7-dioxapentacyclo[10.8.0.0,.0,.0,]icosa-14,17-dien-16-one

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Download Curated Data for this Chemical

1210

Interactors 1
Chemical Interactions 6
Network

Chemical Summary

Budesonide