small molecule

Quetiapine

Synonyms/Brands: Quetiapine, Quetiapina, Quetiapinum, quetiapine f, sandoz quetiapine, Quetiapine fumarate, Quetiapine hemifumarate, 2-[2-(4-Dibenzo[b,F][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol

Quetiapine is indicated for the treatment of schizophrenia as well as for the treatment of acute manic episodes associated with bipolar I disorder. The antipsychotic effect of quetiapine is thought by some to be mediated through antagonist activity at dopamine and serotonin receptors. Specifically the D1 and D2 dopamine, the alpha 1 adrenoreceptor and alpha 2 adrenoreceptor, and 5-HT1A and 5-HT2 serotonin receptor subtypes are antagonized. Quetiapine also has an antagonistic effect on the histamine H1 receptor.

Molecular Formula: C₂₁H₂₅N₃O₂S

Molecular Weight:: 383.507

CAS:: 111974-69-7

ATC:: N05AH04

InChiKey:: URKOMYMAXPYINW-UHFFFAOYSA-N

InChi:: InChI=1S/C21H25N3O2S/c25-14-16-26-15-13-23-9-11-24(12-10-23)21-17-5-1-3-7-19(17)27-20-8-4-2-6-18(20)22-21/h1-8,25H,9-16H2

SMILES:: OCCOCCN1CCN(CC1)C1=NC2=CC=CC=C2SC2=CC=CC=C12

IUPAC Name:: 2-[2-(4-{2-thia-9-azatricyclo[9.4.0.0,]pentadeca-1(15),3,5,7,9,11,13-heptaen-10-yl}piperazin-1-yl)ethoxy]ethan-1-ol

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1212

Interactors 26
Chemical Interactions 51
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Chemical Summary

Quetiapine