small molecule

Floxuridine

Synonyms/Brands: FdU, FUDR, 5FDU, Floxuridin, floxuridine, Floxiridina, Floxuridine, Floxuridinum, Deoxyfluorouridine, Fluorodeoxyuridine, 5-Fluorodeoxyuridine, 2'-Deoxy-5-fluorouridine, Fluoruridine Deoxyribose, 5-Fluoro-2-desoxyuridine, 5-Fluorouracil deoxyriboside, beta-5-Fluoro-2'-deoxyuridine, 5-Fluorouracil 2'-deoxyriboside, 1beta-D-2'-Deoxyribofuranosyl-5-flurouracil, 1-beta-D-2'-Deoxyribofuranosyl-5-flurouracil, 1-(2-Deoxy-beta-D-ribofuranosyl)-5-fluorouracil

An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection. Floxuridine is available as a sterile, nonpyrogenic, lyophilized powder for reconstitution. When administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.

Molecular Formula: C₉H₁₁FN₂O₅

Molecular Weight:: 246.1924

CAS:: 50-91-9

InChiKey:: ODKNJVUHOIMIIZ-RRKCRQDMSA-N

InChi:: InChI=1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1

SMILES:: OC[C@H]1O[C@H](C[C@@H]1O)N1C=C(F)C(=O)NC1=O

IUPAC Name:: 5-fluoro-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione

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Download Curated Data for this Chemical

315

Interactors 2
Chemical Interactions 6
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Chemical Summary

Floxuridine