small molecule

Nisoldipine

Synonyms/Brands: sular, Sular, Nisoldipin, Nisoldipina, Nisoldipine, Nisoldipino, nisoldipine, Nisoldipinum, isobutyl methyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contraction and subsequent vasoconstriction. Nisoldipine may be used in alone or in combination with other agents in the management of hypertension.

Molecular Formula: C₂₀H₂₄N₂O₆

Molecular Weight:: 388.4144

CAS:: 63675-72-9

ATC:: C08CA07

InChiKey:: VKQFCGNPDRICFG-UHFFFAOYSA-N

InChi:: InChI=1S/C20H24N2O6/c1-11(2)10-28-20(24)17-13(4)21-12(3)16(19(23)27-5)18(17)14-8-6-7-9-15(14)22(25)26/h6-9,11,18,21H,10H2,1-5H3

SMILES:: COC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC=C1[N+]([O-])=O)C(=O)OCC(C)C

IUPAC Name:: 3-methyl 5-(2-methylpropyl) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

DrugBank BindingDB ChEMBL PubChem ChemSpider KEGG Drug

Download Curated Data for this Chemical

393

Interactors 5
Chemical Interactions 8
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Chemical Summary

Nisoldipine