small molecule

Dexloxiglumide

Synonyms/Brands: CR 2017, CR-2017

Dexloxiglumide is a selective cholecystokinin type A (CCKA) receptor antagonist in phase III testing by Rottapharm in Europe only, as U.S. trials have been discontinued. As the D-isomer of loxiglumide, it retains all pharmacological properties of loxiglumide but is more potent.

Molecular Formula: C₂₁H₃₀Cl₂N₂O₅

Molecular Weight:: 461.379

CAS:: 119817-90-2

InChiKey:: QNQZBKQEIFTHFZ-GOSISDBHSA-N

InChi:: InChI=1S/C21H30Cl2N2O5/c1-3-4-5-11-25(12-6-13-30-2)21(29)18(9-10-19(26)27)24-20(28)15-7-8-16(22)17(23)14-15/h7-8,14,18H,3-6,9-13H2,1-2H3,(H,24,28)(H,26,27)/t18-/m1/s1

SMILES:: CCCCCN(CCCOC)C(=O)[C@@H](CCC(O)=O)NC(=O)C1=CC(Cl)=C(Cl)C=C1

IUPAC Name:: (4R)-4-[(3,4-dichlorophenyl)formamido]-4-[(3-methoxypropyl)(pentyl)carbamoyl]butanoic acid

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4656

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Chemical Summary

Dexloxiglumide