small molecule
Dextromethorphan
Synonyms/Brands: DM, Dex, DXM, D-methorphan, Dextromethorfan, Dextrometorfano, Dextromthorphane, Dextromethorphan, delta-Methorphan, Dextromethorphanum, (+)-dextromethorphan, tylenol cold and flu nighttime
The d-isomer of the codeine analog of levorphanol. Dextromethorphan shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (receptors, N-methyl-D-aspartate) and acts as a non-competitive channel blocker. It is one of the widely used antitussives, and is also used to study the involvement of glutamate receptors in neurotoxicity.
Molecular Formula: C18H25NO
Molecular Weight:: 271.404
CAS:: 125-71-3
InChiKey:: MKXZASYAUGDDCJ-NJAFHUGGSA-N
InChi:: InChI=1S/C18H25NO/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18/h6-7,12,15,17H,3-5,8-11H2,1-2H3/t15-,17+,18+/m1/s1
SMILES:: [H][C@]12CC3=C(C=C(OC)C=C3)[C@@]3(CCCC[C@]13[H])CCN2C
IUPAC Name:: (1S,9S,10S)-4-methoxy-17-methyl-17-azatetracyclo[7.5.3.0,.0,]heptadeca-2(7),3,5-triene
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