small molecule

GTS-21

Synonyms/Brands: DMXB-A, DMXB-Anabaseine, Dimethoxybenzylidene anabaseine, 3-(2,4-dimethoxybenzylidene)anabaseine
GTS-21 (also known as DMBX-A), is a novel, small-molecule, orally active and selective alpha-7 nicotinic acetylcholine (nACh) receptor agonist that has demonstrated memory and cognition enhancement activity in human clinical trials. Athenagen licensed the exclusive rights to the compound and a related library of analogs as part of the acquisition of Osprey Pharmaceutical Company in April 2006. GTS-21 has been studied in multiple Phase I studies in healthy volunteers and one Phase I/II study in schizophrenic patients. In all studies, the compound was well tolerated. In a Phase I multi-dose, double-blind, placebo controlled study in healthy adults, GTS-21 also demonstrated cognitive enhancement across all doses, with a statistically significant improvement ...
in attention related and memory related tasks (Kitagawa, et al. Neuropsychopharmacology (2003), 28, 542-551).
Molecular Formula: C19H20N2O2
Molecular Weight:: 308.3743
CAS:: 148372-04-7
InChiKey:: RPYWXZCFYPVCNQ-RVDMUPIBSA-N
InChi:: InChI=1S/C19H20N2O2/c1-22-17-8-7-14(18(12-17)23-2)11-15-5-4-10-21-19(15)16-6-3-9-20-13-16/h3,6-9,11-13H,4-5,10H2,1-2H3/b15-11+
SMILES:: [H]\C(=C1\CCCN=C1C1=CN=CC=C1)C1=C(OC)C=C(OC)C=C1
IUPAC Name:: 3-[(3E)-3-[(2,4-dimethoxyphenyl)methylidene]-3,4,5,6-tetrahydropyridin-2-yl]pyridine
Download Curated Data for this Chemical
5295
Switch View:
  • Interactors 1
  • Chemical Interactions 3
  • Network