small molecule

Vismodegib

Synonyms/Brands: GDC-0449, Erivedge, erivedge, Vismodegibum, Hedgehog Antagonist GDC-0449

Vismodegib inhibits the hedgehog signalling pathway and is indicated for treatment of adult basal cell carcinoma. FDA approved on Jan 30, 2012.

Molecular Formula: C₁₉H₁₄Cl₂N₂O₃S

Molecular Weight:: 421.297

CAS:: 879085-55-9

ATC:: L01XX43

InChiKey:: BPQMGSKTAYIVFO-UHFFFAOYSA-N

InChi:: InChI=1S/C19H14Cl2N2O3S/c1-27(25,26)13-6-7-14(17(21)11-13)19(24)23-12-5-8-16(20)15(10-12)18-4-2-3-9-22-18/h2-11H,1H3,(H,23,24)

SMILES:: CS(=O)(=O)C1=CC(Cl)=C(C=C1)C(=O)NC1=CC=C(Cl)C(=C1)C1=CC=CC=N1

IUPAC Name:: 2-chloro-N-[4-chloro-3-(pyridin-2-yl)phenyl]-4-methanesulfonylbenzamide

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7595

Chemical Summary