small molecule

Bivalent ligand 158

Synonyms/Brands: ATTEC, Bivalent_ligand_158
Bivalent ligands are compounds that bridge two protein partners to form a ternary complex, resulting in ubiquitin-proteasome mediated degradation, lysosomal degradation or other means of target protein inactivation. Applies to PROTACs and other heterobifunctional compounds in which two distinct protein binding moieties are connected with a linker, as well as single entity molecular glue compounds that contact both proteins without a linker.
METHOD:: AUTAC/ATTEC (Autophagosome Tethering Compound; structured as a LC3 binding moiety--linker--target binding moiety; target degraded via autophagic degradation)
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8556
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