small molecule

Lorlatinib

Synonyms/Brands: 4CLI, 4CLJ, S7536, D11012, 2641AH, A14207, EX-A828, CS-3983, DB12130, LORVIQUA, LORBRENA, BCP10287, J-690185, AK175603, GTPL7476, HY-12215, Q27285820, LORATINIB, OSP71S83EU, PF06463922, CCG-268718, LORLATINIB, C21H19FN6O2, KS-00000T6C, PF-06463922, PF 06463922, PFE-PKIS 10, MFCD28144520, BDBM50018830, LORLATINIBUM ...
Lorlatinib is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogene 1 (Ros1), with potential antineoplastic activity. Upon administration, lorlatinib binds to and inhibits both ALK and ROS1 kinases. The kinase inhibition leads to disruption of ALK- and ROS1-mediated signaling and eventually inhibits tumor cell growth in ALK- and ROS1-overexpressing tumor cells. In addition, PF-06463922 is able to cross the blood brain barrier. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development; ALK dysregulation and gene rearrangements are associated with a series of tumors. ROS1, overexpressed in certain cancer cells, plays a key role in ...
cell growth and survival of cancer cells.
Molecular Formula: C21H19FN6O2
Molecular Weight:: 406.4
InChiKey:: IIXWYSCJSQVBQM-LLVKDONJSA-N
InChi:: InChI=1S/C21H19FN6O2/c1-11-15-7-13(22)4-5-14(15)21(29)27(2)10-16-19(17(8-23)28(3)26-16)12-6-18(30-11)20(24)25-9-12/h4-7,9,11H,10H2,1-3H3,(H2,24,25)/t11-/m1/s1
IUPAC Name:: (16R)-19-amino-13-fluoro-4,8,16-trimethyl-9-oxo-17-oxa-4,5,8,20-tetrazatetracyclo[16.3.1.02,6.010,15]docosa-1(22),2,5,10(15),11,13,18,20-octaene-3-carbonitrile
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