small molecule

Bivalent ligand 248

Synonyms/Brands: R-CR8, Bivalent_ligand_248
Bivalent ligands are compounds that bridge two protein partners to form a ternary complex, resulting in ubiquitin-proteasome mediated degradation, lysosomal degradation or other means of target protein inactivation. Applies to PROTACs and other heterobifunctional compounds in which two distinct protein binding moieties are connected with a linker, as well as single entity molecular glue compounds that contact both proteins without a linker.
METHOD:: Molecular Glue (Single chemical moiety that contacts both the E3 and the target in a ternary complex; structured as a single chemical entity without linkers; target degraded via UPS or otherwise inactivated in the ternary complex)
Download Curated Data for this Chemical
9807
Switch View:
  • Interactors 2
  • Chemical Interactions 2
  • Network