BAIT

TRR1

caf4, SPBC3F6.03
thioredoxin reductase Trr1
GO Process (0)
GO Function (2)
GO Component (4)

Gene Ontology Cellular Component

Schizosaccharomyces pombe (972h)
PREY

TPX1

SPCC576.03c
thioredoxin peroxidase Tpx1
Schizosaccharomyces pombe (972h)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

A genetic approach to study H2 O2 scavenging in fission yeast - distinct roles of peroxiredoxin and catalase.

Paulo E, Garcia-Santamarina S, Calvo IA, Carmona M, Boronat S, Domenech A, Ayte J, Hidalgo E

The main peroxiredoxin in Schizosaccharomyces pombe, Tpx1, is important to sustain aerobic growth, and cells lacking this protein are only able to grow on solid plates under anaerobic conditions. We have found that deletion of the gene coding for thioredoxin reductase, trr1, is a suppressor of the sensitivity to aerobic growth of Δtpx1 cells, so that cells lacking both proteins ... [more]

Mol. Microbiol. Feb. 13, 2014; 0(0); [Pubmed: 24521463]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)

Additional Notes

  • genetic complex
  • trr1/tpx1/ctt1 triple mutants are synthetic lethal

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
TPX1 TRR1
Phenotypic Suppression
Phenotypic Suppression

A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Low-PomBase
-
TPX1 TRR1
Synthetic Rescue
Synthetic Rescue

A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.

Low-BioGRID
1022579

Curated By

  • BioGRID