BAIT

TRR1

caf4, SPBC3F6.03
thioredoxin reductase Trr1
GO Process (0)
GO Function (2)
GO Component (4)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Schizosaccharomyces pombe (972h)
PREY

CTT1

cta1, SPCC757.07c
catalase
GO Process (1)
GO Function (1)
GO Component (4)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Schizosaccharomyces pombe (972h)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

A genetic approach to study H2 O2 scavenging in fission yeast - distinct roles of peroxiredoxin and catalase.

Paulo E, Garcia-Santamarina S, Calvo IA, Carmona M, Boronat S, Domenech A, Ayte J, Hidalgo E

The main peroxiredoxin in Schizosaccharomyces pombe, Tpx1, is important to sustain aerobic growth, and cells lacking this protein are only able to grow on solid plates under anaerobic conditions. We have found that deletion of the gene coding for thioredoxin reductase, trr1, is a suppressor of the sensitivity to aerobic growth of Δtpx1 cells, so that cells lacking both proteins ... [more]

Mol. Microbiol. Feb. 13, 2014; 0(0); [Pubmed: 24521463]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)

Additional Notes

  • genetic complex
  • trr1/tpx1/ctt1 triple mutants are synthetic lethal

Curated By

  • BioGRID