BCL6
Gene Ontology Biological Process
- B cell differentiation [IGI]
- Rho protein signal transduction [IGI]
- actin cytoskeleton organization [IMP]
- cell morphogenesis [IGI, IMP]
- cellular response to DNA damage stimulus [ISO]
- erythrocyte development [IMP]
- germinal center formation [IMP]
- negative regulation of Notch signaling pathway [IGI]
- negative regulation of Rho protein signal transduction [IMP]
- negative regulation of T-helper 2 cell differentiation [IGI]
- negative regulation of apoptotic process [IDA, IMP]
- negative regulation of cell differentiation [IMP]
- negative regulation of cell growth [ISO]
- negative regulation of cell proliferation [IMP]
- negative regulation of cell-matrix adhesion [IMP]
- negative regulation of cellular senescence [IMP]
- negative regulation of isotype switching to IgE isotypes [IGI, IMP]
- negative regulation of mast cell cytokine production [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- negative regulation of transcription, DNA-templated [ISO]
- negative regulation of type 2 immune response [IGI]
- positive regulation of B cell proliferation [IMP]
- positive regulation of apoptotic process [ISO]
- positive regulation of cellular component movement [IMP]
- positive regulation of histone deacetylation [IGI]
- positive regulation of neuron differentiation [IDA]
- protein import into nucleus, translocation [ISO]
- protein localization [IMP]
- regulation of Rho GTPase activity [IMP]
- regulation of cell proliferation [IMP]
- regulation of inflammatory response [IMP]
- regulation of memory T cell differentiation [IMP]
- regulation of transcription from RNA polymerase II promoter [IGI]
- spermatogenesis [IMP]
- transcription from RNA polymerase II promoter [IDA]
- type 2 immune response [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- chromatin DNA binding [IDA]
- chromatin binding [IDA, ISO]
- intronic transcription regulatory region sequence-specific DNA binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- DNA binding [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- chromatin DNA binding [IDA]
- chromatin binding [IDA, ISO]
- intronic transcription regulatory region sequence-specific DNA binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
Gene Ontology Cellular Component
BCL6B
Gene Ontology Biological Process
Gene Ontology Molecular Function
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A peptide aptamer to antagonize BCL-6 function.
BCL-6 is a transcription factor essential for germinal centre B-cell development. The BCL-6 gene is involved in diffuse large-cell lymphoma and overexpressed in other types of non-Hodgkin's lymphoma and in high-grade breast cancer. BCL-6 is a transcriptional repressor whose N-terminal POZ domain mediates protein-protein interactions to exert its effects. Reasoning that disruption of POZ domain-mediated interactions may be an effective ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| BCL6B BCL6 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| BCL6 BCL6B | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| BCL6B BCL6 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |
Curated By
- BioGRID