PREY

MED23

ARC130, CRSP130, CRSP133, CRSP3, DRIP130, MRT18, SUR-2, SUR2, RP5-914N13.2
mediator complex subunit 23
Homo sapiens

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

A gene-expression inhibitor that targets an alpha-helix-mediated protein interaction.

Asada S, Choi Y, Uesugi M

Protein-protein interactions are harder to target by small organic molecules than by enzymes or nuclear hormone receptors. Here we report the discovery of an organic compound that inhibits the expression of the Her2 oncogene by disrupting an alpha-helix-mediated protein interaction. The druglike molecule we named adamanolol competitively inhibited the interaction between the two cancer-linked nuclear proteins, ESX (an epithelial-specific transcription ... [more]

J. Am. Chem. Soc. Apr. 30, 2003; 125(17);4992-3 [Pubmed: 12708845]

Throughput

  • Low Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
ELF3 MED23
Phenotypic Suppression
Phenotypic Suppression

A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Low-BioGRID
-
ELF3 MED23
Protein-peptide
Protein-peptide

An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.

Low-BioGRID
-
ELF3 MED23
Reconstituted Complex
Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Low-BioGRID
-
MED23 ELF3
Reconstituted Complex
Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Low-BioGRID
-
MED23 ELF3
Reconstituted Complex
Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Low-BioGRID
-

Curated By

  • BioGRID