Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Cooperative control of striated muscle mass and metabolism by MuRF1 and MuRF2.

Witt CC, Witt SH, Lerche S, Labeit D, Back W, Labeit S

The muscle-specific RING finger proteins MuRF1 and MuRF2 have been proposed to regulate protein degradation and gene expression in muscle tissues. We have tested the in vivo roles of MuRF1 and MuRF2 for muscle metabolism by using knockout (KO) mouse models. Single MuRF1 and MuRF2 KO mice are healthy and have normal muscles. Double knockout (dKO) mice obtained by the ... [more]

EMBO J. Jan. 23, 2008; 27(2);350-60 [Pubmed: 18157088]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

TRIM63

Gene Ontology Biological Process

Gene Ontology Molecular Function

protein binding [IPI]signal transducer activity [NAS]titin binding [IDA]

Gene Ontology Cellular Component

NEBL

Gene Ontology Biological Process

Gene Ontology Molecular Function

actin filament binding [IDA]cytoskeletal protein binding [IDA, IPI]filamin binding [IPI]protein binding [IPI]structural constituent of muscle [NAS]tropomyosin binding [IPI]

Gene Ontology Cellular Component

Two-hybrid

Publication

Cooperative control of striated muscle mass and metabolism by MuRF1 and MuRF2.

Throughput

Curated By

protein binding [IPI]
signal transducer activity [NAS]
titin binding [IDA]

actin filament binding [IDA]
cytoskeletal protein binding [IDA, IPI]
filamin binding [IPI]
protein binding [IPI]
structural constituent of muscle [NAS]
tropomyosin binding [IPI]