BAIT
SGF73
SPCC126.04c
SAGA complex subunit Sgf73
GO Process (6)
GO Function (0)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
SIR2
SPBC16D10.07c
Sir2 family histone deacetylase Sir2
GO Process (12)
GO Function (8)
GO Component (5)
Gene Ontology Biological Process
- chromatin silencing [IMP]
- chromatin silencing at centromere [IMP]
- chromatin silencing at silent mating-type cassette [IGI, IMP]
- chromatin silencing at telomere [IMP]
- histone H3 deacetylation [IDA]
- histone H3-K9 modification [IDA]
- histone H4 deacetylation [IDA]
- histone deacetylation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IEP]
- positive regulation of heterochromatin assembly [EXP]
- protein localization to chromosome, telomeric region [IMP]
- regulation of histone H3-K9 methylation [IMP]
Gene Ontology Molecular Function- NAD+ binding [IDA]
- NAD-dependent histone deacetylase activity (H3-K9 specific) [IDA]
- NAD-dependent histone deacetylase activity (H4-K16 specific) [IDA]
- histone deacetylase activity [IDA]
- histone deacetylase activity (H3-K14 specific) [IDA]
- histone deacetylase activity (H3-K4 specific) [IDA]
- histone deacetylase activity (H3-K9 specific) [IDA]
- histone deacetylase activity (H4-K16 specific) [IDA]
- NAD+ binding [IDA]
- NAD-dependent histone deacetylase activity (H3-K9 specific) [IDA]
- NAD-dependent histone deacetylase activity (H4-K16 specific) [IDA]
- histone deacetylase activity [IDA]
- histone deacetylase activity (H3-K14 specific) [IDA]
- histone deacetylase activity (H3-K4 specific) [IDA]
- histone deacetylase activity (H3-K9 specific) [IDA]
- histone deacetylase activity (H4-K16 specific) [IDA]
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Large scale screening of genetic interaction with sgf73(+) in fission yeast.
Genetic interaction (GI) not only suggests functional correlations between different genes in vivo, but also provides clues for understanding the potential biological function of a specific gene. Screening of GI is an important method for understanding GI between different genes. In this study, we selected sgf73⺠as a query, which encodes a subunit of SAGA (Spt-Ada-Gcn5 acetyltransferase) complex deubiquitination module, ... [more]
Yi Chuan Jul. 01, 2014; 36(7);723-31 [Pubmed: 25076038]
Throughput
- High Throughput
Additional Notes
- validated by low throughput assay.
Curated By
- BioGRID