NAA20, RAD56, S000007464, S000029405, L000001576, YPR131C
Catalytic subunit of the NatB N-terminal acetyltransferase; NatB catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met
GO Process (3)
GO Function (1)
GO Component (2)
Saccharomyces cerevisiae (S288c)


1,3-beta-glucanosyltransferase; has similarity to Gas1p; localizes to the cell wall
GO Process (1)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.


Synthetic lethal screen of NAA20, a catalytic subunit gene of NatB N-Terminal acetylase in Saccharomyces cerevisiae.

Lee KE, Ahn JY, Kim JM, Hwang CS

The Saccharomyces cerevisiae NatB N-terminal acetylase contains a catalytic subunit Naa20 and an auxiliary subunit Naa25. To elucidate the cellular functions of the NatB, we utilized the Synthetic Genetic Array to screen for genes that are essential for cell growth in the absence of NAA20. The genome-wide synthetic lethal screen of NAA20 identified genes encoding for serine/threonine protein kinase Vps15, ... [more]

J. Microbiol. Aug. 27, 2014; 0(0); [Pubmed: 25163837]


  • Low Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)

Additional Notes

  • Figure 2
  • SGA, random spore analysis

Curated By

  • BioGRID