A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

CPF-associated phosphatase activity opposes condensin-mediated chromosome condensation.

Vanoosthuyse V, Legros P, van der Sar SJ, Yvert G, Toda K, Le Bihan T, Watanabe Y, Hardwick K, Bernard P

Functional links connecting gene transcription and condensin-mediated chromosome condensation have been established in species ranging from prokaryotes to vertebrates. However, the exact nature of these links remains misunderstood. Here we show in fission yeast that the 3' end RNA processing factor Swd2.2, a component of the Cleavage and Polyadenylation Factor (CPF), is a negative regulator of condensin-mediated chromosome condensation. Lack ... [more]

PLoS Genet. Jun. 01, 2014; 10(6);e1004415 [Pubmed: 24945319]

Throughput

Low Throughput

Ontology Terms

phenotype: inviable (APO:0000112)

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
PPN1 SSU72	Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.	Vanoosthuyse V (2014)	High	-	BioGRID	-
PPN1 SSU72	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Sanchez AM (2018)	Low	-	BioGRID	2623324

Curated By

BioGRID

Interaction Summary

SSU72

Gene Ontology Biological Process

Gene Ontology Molecular Function

phosphoric ester hydrolase activity [ISO]

Gene Ontology Cellular Component

PPN1