EPE1
Gene Ontology Biological Process
- chromatin remodeling [IMP]
- histone H3-K36 demethylation [ISO]
- mitotic sister chromatid segregation [IMP]
- negative regulation of extent of heterochromatin assembly [IMP]
- regulation of chromatin assembly or disassembly [IMP]
- regulation of chromatin silencing at centromere [IMP]
- regulation of chromatin silencing at silent mating-type cassette [IMP]
- regulation of extent of heterochromatin assembly [IMP]
- regulation of transcription from RNA polymerase II promoter [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SCK2
Gene Ontology Biological Process
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.
Heterochromatin spreading leads to the silencing of genes within its path, and boundary elements have evolved to constrain such spreading. In fission yeast, heterochromatin at centromeres I and III is flanked by inverted repeats termed IRCs, which are required for proper boundary functions. However, the mechanisms by which IRCs prevent heterochromatin spreading are unknown. Here, we identified Bdf2, which is ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SCK2 EPE1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | - | BioGRID | - |
Curated By
- BioGRID