NSE1
Gene Ontology Biological Process
Gene Ontology Molecular Function
TOP2
Gene Ontology Biological Process
- DNA strand elongation involved in mitotic DNA replication [ISO]
- DNA topological change [IDA, IGI, IMP]
- chromatin organization [IGI]
- mitotic chromosome condensation [IMP]
- resolution of meiotic recombination intermediates [IMP]
- transcription of nuclear large rRNA transcript from RNA polymerase I promoter [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
H2A.Z-dependent regulation of cohesin dynamics on chromosome arms.
Structural maintenance of chromosomes (SMC) complexes and DNA topoisomerases are major determinants of chromosome structure and dynamics. The cohesin complex embraces sister chromatids throughout interphase, but during mitosis most cohesin is stripped from chromosome arms by early prophase, while the remaining cohesin at kinetochores is cleaved at anaphase. This two-step removal of cohesin is required for sister chromatids to separate. ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Additional Notes
- Figure 1
- nse1-C216S top2-191 double mutant is synthetic lethal
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NSE1 TOP2 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 1026441 |
Curated By
- BioGRID