A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Synergies between Aip1p and capping protein subunits (Acp1p and Acp2p) in clathrin-mediated endocytosis and cell polarization in fission yeast.

Berro J, Pollard TD

Aip1p cooperates with ADF/cofilin to disassemble actin filaments in vitro and in vivo, and is proposed to cap actin filament barbed ends. In this paper, we address the synergies between Aip1p and the capping protein heterodimer, Acp1p/Acp2p, during clathrin-mediated endocytosis in fission yeast. Using quantitative microscopy and new methods for data alignment and analysis (Berro and Pollard, 2014) we show ... [more]

Mol. Biol. Cell Aug. 20, 2014; 0(0); [Pubmed: 25143407]

Throughput

Low Throughput

Ontology Terms

phenotype: inviable (APO:0000112)

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
AIP1 ACP2	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Chen Q (2015)	Low	-	PomBase	-

Curated By

BioGRID

Interaction Summary

AIP1

Gene Ontology Biological Process

Gene Ontology Cellular Component

ACP2