TICAM1
Gene Ontology Biological Process
- MyD88-independent toll-like receptor signaling pathway [IMP]
- apoptotic signaling pathway [IMP]
- defense response to virus [IMP]
- lipopolysaccharide-mediated signaling pathway [IMP]
- macrophage activation involved in immune response [IMP]
- positive regulation of B cell activation [IMP]
- positive regulation of B cell proliferation [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IGI, IMP, ISO]
- positive regulation of NF-kappaB transcription factor activity [IGI, IMP]
- positive regulation of chemokine biosynthetic process [IGI, IMP]
- positive regulation of interferon-beta biosynthetic process [IMP]
- positive regulation of interleukin-6 production [IMP]
- positive regulation of natural killer cell activation [IMP]
- positive regulation of nitric oxide biosynthetic process [IMP]
- positive regulation of protein binding [IDA]
- positive regulation of protein ubiquitination [IDA]
- positive regulation of tumor necrosis factor production [IDA, IGI, IMP]
- positive regulation of type I interferon production [IMP]
- regulation of protein homodimerization activity [IMP]
- response to exogenous dsRNA [IDA, IMP, ISO]
- response to lipopolysaccharide [IGI, IMP]
- signal transduction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
BECN1
Gene Ontology Biological Process
- CVT pathway [IBA]
- autophagic vacuole assembly [IBA, ISO]
- autophagy [IDA, IMP, ISO]
- beta-amyloid metabolic process [IMP]
- cellular response to nitrogen starvation [IBA]
- cytokinesis [ISO]
- late endosome to vacuole transport [IBA]
- lysosome organization [IMP]
- negative regulation of cell death [ISO]
- negative regulation of cell proliferation [IDA]
- neuron development [IMP]
- nucleophagy [IBA]
- positive regulation of autophagy [ISO]
- positive regulation of macroautophagy [IGI]
- positive regulation of mitochondrion degradation [ISO]
- regulation of catalytic activity [IMP]
- response to other organism [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cytoplasm [IDA, ISO]
- cytoplasmic membrane-bounded vesicle [IDA]
- cytoskeleton [ISS]
- dendrite [ISO]
- extrinsic component of membrane [IBA]
- membrane [ISS]
- nucleus [ISO]
- phagocytic vesicle [IDA]
- phosphatidylinositol 3-kinase complex, class III, type I [IBA]
- phosphatidylinositol 3-kinase complex, class III, type II [IBA]
- pre-autophagosomal structure [IBA]
- protein complex [IDA]
- trans-Golgi network [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
MyD88 and Trif target Beclin 1 to trigger autophagy in macrophages.
The Toll-like receptors (TLR) play an instructive role in innate and adaptive immunity by recognizing specific molecular patterns from pathogens. Autophagy removes intracellular pathogens and participates in antigen presentation. Here, we demonstrate that not only TLR4, but also other TLR family members induce autophagy in macrophages, which is inhibited by MyD88, Trif, or Beclin 1 shRNA expression. MyD88 and Trif ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| BECN1 TICAM1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID