RPS6KB1
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [ISO]
- TOR signaling [ISO]
- cellular response to growth factor stimulus [ISO]
- germ cell development [IDA]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- negative regulation of insulin receptor signaling pathway [ISO]
- positive regulation of mitotic cell cycle [ISO]
- positive regulation of skeletal muscle tissue growth [ISO]
- positive regulation of smooth muscle cell migration [ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of translation [ISO]
- positive regulation of translational initiation [ISO]
- protein kinase B signaling [IGI]
- protein phosphorylation [IDA, IMP, ISO]
- regulation of glucose import [ISO]
- response to insulin [ISO]
- response to tumor necrosis factor [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RPS6
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IMP]
- T cell differentiation in thymus [IGI, IMP]
- T cell proliferation involved in immune response [IGI, IMP]
- TOR signaling [ISO]
- activation-induced cell death of T cells [IMP]
- erythrocyte development [IMP]
- gastrulation [IGI, IMP]
- glucose homeostasis [IDA]
- mitotic cell cycle checkpoint [IMP]
- mitotic nuclear division [IMP]
- negative regulation of apoptotic process [IMP]
- oogenesis stage [IMP]
- placenta development [IMP]
- positive regulation of apoptotic process [ISO]
- rRNA processing [IMP, ISO]
- ribosomal small subunit biogenesis [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell body [ISO]
- cytoplasm [IDA, ISO]
- cytoplasmic ribonucleoprotein granule [ISO]
- cytosolic small ribosomal subunit [IBA, IDA, ISO]
- dendrite [IDA, ISO]
- membrane [ISO]
- nucleolus [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [IDA]
- polysome [IDA]
- ribonucleoprotein complex [ISO]
- ribosome [IDA]
- small ribosomal subunit [ISO]
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Syndecan-4 regulates subcellular localization of mTOR Complex2 and Akt activation in a PKCalpha-dependent manner in endothelial cells.
Mammalian target of rapamycin (mTOR) activity is regulated by assembly of two functionally distinct complexes, mTORC1 and mTORC2. In syndecan-4 (S4) null endothelial cells, mTORC2 activity is reduced, resulting in decreased Akt activation, while mTORC1 activity is increased. Levels of rictor, mLST8, and mSin-1 are unchanged in total cell lysates but decreased in the rafts of S4(-/-) endothelial cells, as ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID