ZIC3
Gene Ontology Biological Process
- determination of digestive tract left/right asymmetry [IMP]
- determination of left/right symmetry [IMP]
- determination of liver left/right asymmetry [IMP]
- determination of pancreatic left/right asymmetry [IMP]
- heart looping [IMP]
- lung development [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [ISS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
SRF
Gene Ontology Biological Process
- angiogenesis involved in wound healing [TAS]
- cell migration involved in sprouting angiogenesis [IMP]
- cellular senescence [IMP]
- heart development [ISS]
- heart looping [ISS]
- mRNA transcription from RNA polymerase II promoter [ISS]
- muscle cell cellular homeostasis [ISS]
- negative regulation of beta-amyloid clearance [IMP]
- neuron development [TAS]
- positive regulation of cell differentiation [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of smooth muscle contraction [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation [IGI]
- positive regulation of transcription initiation from RNA polymerase II promoter [IDA]
- positive regulation of transcription via serum response element binding [IDA]
- regulation of smooth muscle cell differentiation [TAS]
- response to cytokine [IMP, NAS]
- response to hormone [IDA]
- response to hypoxia [IEP]
- response to toxic substance [TAS]
- transcription from RNA polymerase II promoter [IDA]
- trophectodermal cell differentiation [IDA]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [IMP]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISS]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- serum response element binding [IDA]
- transcription factor binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [IMP]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISS]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- serum response element binding [IDA]
- transcription factor binding [IPI]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Identification of a novel role of ZIC3 in regulating cardiac development.
Mutations in ZIC3 cause X-linked heterotaxy, a disorder characterized by abnormal lateralization of normally asymmetric thoracic and abdominal organs. Animal models demonstrate an early role for ZIC3 in embryonic left-right (LR) patterning. ZIC3 mutations have also been described in patients with isolated cardiovascular malformations. We wished to address the hypothesis that ZIC3 has plieotropic effects in development and may regulate ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID