BAIT
ARRB2
AI326910, AW122872, DN-491F10.4
arrestin, beta 2
GO Process (38)
GO Function (18)
GO Component (10)
Gene Ontology Biological Process
- G-protein coupled receptor internalization [ISO]
- G-protein coupled receptor signaling pathway [ISO]
- adult walking behavior [IMP]
- cell chemotaxis [ISO]
- desensitization of G-protein coupled receptor protein signaling pathway by arrestin [ISO]
- detection of temperature stimulus involved in sensory perception of pain [ISO]
- endocytosis [ISO]
- follicle-stimulating hormone signaling pathway [ISO]
- negative regulation of GTPase activity [ISO]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of interleukin-1 beta production [IMP]
- negative regulation of interleukin-12 production [IMP]
- negative regulation of interleukin-6 production [IMP]
- negative regulation of natural killer cell mediated cytotoxicity [ISO]
- negative regulation of protein ubiquitination [ISO]
- negative regulation of release of cytochrome c from mitochondria [ISO]
- negative regulation of smooth muscle cell apoptotic process [ISO]
- negative regulation of toll-like receptor signaling pathway [IMP]
- negative regulation of tumor necrosis factor production [IMP]
- positive regulation of DNA biosynthetic process [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of calcium ion transport [ISO]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of protein kinase B signaling [IMP, ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of protein ubiquitination [ISO]
- positive regulation of receptor internalization [ISO]
- positive regulation of synaptic transmission, dopaminergic [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO]
- protein ubiquitination [ISO]
- receptor internalization [ISO]
- regulation of G-protein coupled receptor protein signaling pathway [IMP, ISO]
- regulation of androgen receptor signaling pathway [ISO]
- regulation of protein phosphorylation [IDA, IGI]
- transcription from RNA polymerase II promoter [ISO]
- transforming growth factor beta receptor signaling pathway [ISO]
Gene Ontology Molecular Function- 14-3-3 protein binding [ISO]
- D1 dopamine receptor binding [ISO]
- G-protein coupled receptor binding [ISO]
- alpha-1A adrenergic receptor binding [ISO]
- alpha-1B adrenergic receptor binding [ISO]
- angiotensin receptor binding [ISO]
- enzyme binding [ISO]
- follicle-stimulating hormone receptor binding [ISO]
- mitogen-activated protein kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein complex scaffold [ISO]
- protein domain specific binding [ISO]
- protein kinase B binding [IPI]
- receptor binding [ISO]
- type 1 angiotensin receptor binding [ISO]
- type 2A serotonin receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- 14-3-3 protein binding [ISO]
- D1 dopamine receptor binding [ISO]
- G-protein coupled receptor binding [ISO]
- alpha-1A adrenergic receptor binding [ISO]
- alpha-1B adrenergic receptor binding [ISO]
- angiotensin receptor binding [ISO]
- enzyme binding [ISO]
- follicle-stimulating hormone receptor binding [ISO]
- mitogen-activated protein kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein complex scaffold [ISO]
- protein domain specific binding [ISO]
- protein kinase B binding [IPI]
- receptor binding [ISO]
- type 1 angiotensin receptor binding [ISO]
- type 2A serotonin receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
GSK3B
7330414F15Rik, 8430431H08Rik, C86142, GSK-3, GSK-3beta, GSK3
glycogen synthase kinase 3 beta
GO Process (56)
GO Function (17)
GO Component (19)
Gene Ontology Biological Process
- ER overload response [IDA, ISO]
- Wnt signaling pathway [IGI]
- axonogenesis [IGI]
- canonical Wnt signaling pathway [IDA, ISO]
- canonical Wnt signaling pathway involved in positive regulation of apoptotic process [IMP]
- cell migration [IGI]
- cell proliferation [TAS]
- cellular response to interleukin-3 [IDA]
- cellular response to mechanical stimulus [ISO]
- circadian rhythm [IMP]
- cytoskeleton organization [TAS]
- epithelial to mesenchymal transition [ISO]
- establishment of cell polarity [ISO]
- establishment or maintenance of cell polarity [ISO]
- extrinsic apoptotic signaling pathway in absence of ligand [IDA]
- fat cell differentiation [IDA]
- glycogen metabolic process [ISO]
- hippocampus development [ISO]
- hypermethylation of CpG island [IMP]
- intracellular signal transduction [ISO]
- myoblast fusion [IDA, IGI]
- myotube differentiation [IGI]
- negative regulation of MAP kinase activity [ISO]
- negative regulation of NFAT protein import into nucleus [ISO]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of cardiac muscle hypertrophy [IDA]
- negative regulation of dendrite morphogenesis [ISO]
- negative regulation of neuron maturation [IGI]
- negative regulation of neuron projection development [IGI, IMP]
- negative regulation of protein binding [ISO]
- negative regulation of protein complex assembly [ISO]
- organ morphogenesis [IMP]
- peptidyl-serine phosphorylation [IDA, ISO]
- phosphorylation [IMP]
- positive regulation of Rac GTPase activity [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of axon extension [IGI]
- positive regulation of cell-matrix adhesion [ISO]
- positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [IDA]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of peptidyl-threonine phosphorylation [IDA]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IGI]
- positive regulation of protein binding [IDA]
- positive regulation of protein complex assembly [ISO]
- positive regulation of protein export from nucleus [ISO]
- positive regulation of stem cell differentiation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- protein export from nucleus [IDA]
- protein localization to microtubule [IGI]
- protein phosphorylation [IDA, IGI, IMP, ISO, ISS]
- re-entry into mitotic cell cycle [IDA]
- regulation of gene expression by genetic imprinting [IMP]
- regulation of microtubule-based process [IDA, ISO]
- regulation of neuron projection development [IGI]
- regulation of neuronal synaptic plasticity [ISO]
- superior temporal gyrus development [ISO]
Gene Ontology Molecular Function- ATP binding [ISO]
- NF-kappaB binding [ISO]
- RNA polymerase II transcription factor binding [ISO]
- beta-catenin binding [IPI, ISO]
- integrin binding [ISO]
- ionotropic glutamate receptor binding [ISO]
- kinase activity [ISO]
- p53 binding [ISO]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [ISO]
- protein kinase activity [IDA]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA, IMP, ISO, ISS]
- tau protein binding [ISO]
- tau-protein kinase activity [IDA, ISO]
- transcription factor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- ATP binding [ISO]
- NF-kappaB binding [ISO]
- RNA polymerase II transcription factor binding [ISO]
- beta-catenin binding [IPI, ISO]
- integrin binding [ISO]
- ionotropic glutamate receptor binding [ISO]
- kinase activity [ISO]
- p53 binding [ISO]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [ISO]
- protein kinase activity [IDA]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA, IMP, ISO, ISS]
- tau protein binding [ISO]
- tau-protein kinase activity [IDA, ISO]
- transcription factor binding [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- beta-catenin destruction complex [IDA, ISO]
- cell body [IDA]
- centrosome [ISO]
- cytoplasm [ISO]
- cytosol [IDA, ISO]
- dendritic shaft [IDA]
- dendritic spine [ISO]
- growth cone [IDA]
- membrane [ISO]
- membrane raft [ISO]
- membrane-bounded organelle [IDA]
- neuronal cell body [IDA]
- neuronal postsynaptic density [IDA]
- nucleoplasm [ISO]
- nucleus [IDA, ISO]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [ISO]
- protein complex [ISO]
- ribonucleoprotein complex [IDA]
Mus musculus
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior.
Dopamine plays an important role in the etiology of schizophrenia, and D2 class dopamine receptors are the best-established target of antipsychotic drugs. Here we show that D2 class-receptor-mediated Akt regulation involves the formation of signaling complexes containing beta-arrestin 2, PP2A, and Akt. beta-arrestin 2 deficiency in mice results in reduction of dopamine-dependent behaviors, loss of Akt regulation by dopamine in ... [more]
Cell Jul. 29, 2005; 122(2);261-73 [Pubmed: 16051150]
Throughput
- Low Throughput
Additional Notes
- species unclear
Curated By
- BioGRID