CAMKK2
Gene Ontology Biological Process
Gene Ontology Molecular Function
PRKAA2
Gene Ontology Biological Process
- cellular response to glucose starvation [ISO, ISS]
- cellular response to nutrient levels [ISO, ISS]
- cellular response to organonitrogen compound [IEP]
- fatty acid homeostasis [IDA]
- glucose homeostasis [ISO, ISS]
- histone-serine phosphorylation [ISO, ISS]
- lipid biosynthetic process [ISO, ISS]
- negative regulation of TOR signaling [ISO, ISS]
- negative regulation of apoptotic process [ISO, ISS]
- positive regulation of autophagy [ISO, ISS]
- positive regulation of glycolytic process [IDA]
- protein heterooligomerization [IDA]
- protein phosphorylation [IDA, ISO]
- regulation of circadian rhythm [ISO, ISS]
- regulation of energy homeostasis [IDA]
- regulation of lipid metabolic process [IDA]
- response to activity [IDA]
- response to caffeine [IDA]
Gene Ontology Molecular Function- AMP-activated protein kinase activity [IDA, IMP, ISO]
- ATP binding [IDA]
- chromatin binding [ISO, ISS]
- histone serine kinase activity [ISO, ISS]
- protein binding [IPI]
- protein binding, bridging [IDA]
- protein kinase activity [IDA]
- protein serine/threonine kinase activity [IDA, ISO]
- protein serine/threonine/tyrosine kinase activity [ISO]
- AMP-activated protein kinase activity [IDA, IMP, ISO]
- ATP binding [IDA]
- chromatin binding [ISO, ISS]
- histone serine kinase activity [ISO, ISS]
- protein binding [IPI]
- protein binding, bridging [IDA]
- protein kinase activity [IDA]
- protein serine/threonine kinase activity [IDA, ISO]
- protein serine/threonine/tyrosine kinase activity [ISO]
Gene Ontology Cellular Component
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells.
AMP-activated protein kinase (AMPK) is the downstream component of a kinase cascade that plays a pivotal role in energy homeostasis. Activation of AMPK requires phosphorylation of threonine 172 (T172) within the T loop region of the catalytic alpha subunit. Recently, LKB1 was shown to activate AMPK. Here we show that AMPK is also activated by Ca(2+)/calmodulin-dependent protein kinase kinase (CaMKK). ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID