GSN
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ITCH
Gene Ontology Biological Process
- Notch signaling pathway [TAS]
- inflammatory response [NAS]
- innate immune response [TAS]
- negative regulation of JNK cascade [ISS]
- negative regulation of NF-kappaB transcription factor activity [ISS]
- negative regulation of apoptotic process [IMP]
- negative regulation of defense response to virus [IMP]
- negative regulation of type I interferon production [TAS]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- nucleotide-binding oligomerization domain containing signaling pathway [TAS]
- protein K29-linked ubiquitination [IDA]
- protein K48-linked ubiquitination [IDA]
- protein K63-linked ubiquitination [IDA]
- protein ubiquitination [IDA]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IBA]
- regulation of cell growth [NAS]
- regulation of protein deubiquitination [ISS]
- ubiquitin-dependent protein catabolic process [IDA, NAS]
- viral entry into host cell [TAS]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Cell fate regulation by gelsolin in human gynecologic cancers.
Chemoresistance is a major hurdle in cancer treatment. Down-regulation of apoptosis pathways is one of the key determinants for chemoresistance. Here, we report higher gelsolin (GSN) levels in chemoresistant gynecological cancer cells compared with their sensitive counterparts. cis-Diammine dichloroplatinium (II) (CDDP)-induced GSN down-regulation is associated with its cleavage and apoptosis. Although the C-terminal GSN fragment (C-GSN) sensitized chemoresistant cells to ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID