BAIT

TRIM58

BIA2
tripartite motif containing 58
UPS Project
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY

DYNC1LI2

DNCLI2, LIC2
dynein, cytoplasmic 1, light intermediate chain 2
GO Process (1)
GO Function (0)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Trim58 degrades Dynein and regulates terminal erythropoiesis.

Thom CS, Traxler EA, Khandros E, Nickas JM, Zhou OY, Lazarus JE, Silva AP, Prabhu D, Yao Y, Aribeana C, Fuchs SY, Mackay JP, Holzbaur EL, Weiss MJ

TRIM58 is an E3 ubiquitin ligase superfamily member implicated by genome-wide association studies to regulate human erythrocyte traits. Here, we show that Trim58 expression is induced during late erythropoiesis and that its depletion by small hairpin RNAs (shRNAs) inhibits the maturation of late-stage nucleated erythroblasts to anucleate reticulocytes. Imaging flow cytometry studies demonstrate that Trim58 regulates polarization and/or extrusion of ... [more]

Dev. Cell Sep. 29, 2014; 30(6);688-700 [Pubmed: 25241935]

Throughput

  • Low Throughput

Curated By

  • BioGRID