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BAIT

ITGAM

CD11B, CR3A, MAC-1, MAC1A, MO1A, SLEB6

integrin, alpha M (complement component 3 receptor 3 subunit)

GO Process (8)

GO Function (2)

GO Component (3)

Gene Ontology Biological Process

blood coagulation [TAS]

cell adhesion [TAS]

ectodermal cell differentiation [IEP]

extracellular matrix organization [TAS]

innate immune response [TAS]

leukocyte migration [TAS]

toll-like receptor 4 signaling pathway [TAS]

toll-like receptor signaling pathway [TAS]

Gene Ontology Molecular Function

glycoprotein binding [IPI]
protein binding [IPI]

Gene Ontology Cellular Component

cell surface [IDA]

extracellular vesicular exosome [IDA]

plasma membrane [TAS]

CRISPR Database HGNC Alliance of Genome Resources OMIM VEGA Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

SHARPIN

SIPL1, PSEC0216

SHANK-associated RH domain interactor

GO Process (5)

GO Function (2)

GO Component (5)

Gene Ontology Biological Process

negative regulation of inflammatory response [ISS]

positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]

protein linear polyubiquitination [IDA]

regulation of CD40 signaling pathway [IDA]

regulation of tumor necrosis factor-mediated signaling pathway [IDA]

Gene Ontology Molecular Function

polyubiquitin binding [IDA]
protein binding [IPI]

Gene Ontology Cellular Component

LUBAC complex [IDA]

cytoplasm [IDA]

nucleoplasm [IDA]

CRISPR Database OMIM VEGA HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Protein-peptide

An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.

Publication

SHARPIN regulates uropod detachment in migrating lymphocytes.

Pouwels J, De Franceschi N, Rantakari P, Auvinen K, Karikoski M, Mattila E, Potter C, Sundberg JP, Hogg N, Gahmberg CG, Salmi M, Ivaska J

SHARPIN-deficient mice display a multiorgan chronic inflammatory phenotype suggestive of altered leukocyte migration. We therefore studied the role of SHARPIN in lymphocyte adhesion, polarization, and migration. We found that SHARPIN localizes to the trailing edges (uropods) of both mouse and human chemokine-activated lymphocytes migrating on intercellular adhesion molecule-1 (ICAM-1), which is one of the major endothelial ligands for migrating leukocytes. ... [more]

Cell Rep Nov. 14, 2013; 5(3);619-28 [Pubmed: 24210817]

Throughput

Low Throughput

Curated By

BioGRID