BAIT
ARP8
SPAC664.02c
actin-like protein, Ino80 complex subunit Arp8
GO Process (1)
GO Function (0)
GO Component (3)
Gene Ontology Biological Process
Schizosaccharomyces pombe (972h)
PREY
TOP2
ptr11, SPBC1A4.03c
DNA topoisomerase II
GO Process (6)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
- DNA strand elongation involved in mitotic DNA replication [ISO]
- DNA topological change [IDA, IGI, IMP]
- chromatin organization [IGI]
- mitotic chromosome condensation [IMP]
- resolution of meiotic recombination intermediates [IMP]
- transcription of nuclear large rRNA transcript from RNA polymerase I promoter [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
H2A.Z-dependent regulation of cohesin dynamics on chromosome arms.
Structural maintenance of chromosomes (SMC) complexes and DNA topoisomerases are major determinants of chromosome structure and dynamics. The cohesin complex embraces sister chromatids throughout interphase, but during mitosis most cohesin is stripped from chromosome arms by early prophase, while the remaining cohesin at kinetochores is cleaved at anaphase. This two-step removal of cohesin is required for sister chromatids to separate. ... [more]
Mol. Cell. Biol. Jun. 01, 2014; 34(11);2092-104 [Pubmed: 24687850]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Additional Notes
- Figure 3
- arp8 top2-191 is synthetic lethal
Curated By
- BioGRID