BAIT
INSR
4932439J01Rik, CD220, D630014A15Rik, IR, IR-A, IR-B
insulin receptor
GO Process (43)
GO Function (20)
GO Component (12)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISO]
- activation of MAPK activity [ISO]
- activation of protein kinase B activity [ISO]
- activation of protein kinase activity [ISO]
- cellular response to growth factor stimulus [IDA]
- cellular response to insulin stimulus [ISO]
- epidermis development [IMP]
- exocrine pancreas development [IMP]
- glucose homeostasis [ISO]
- heart morphogenesis [ISO]
- insulin receptor signaling pathway [IMP, ISO]
- intracellular signal transduction [ISO]
- male sex determination [IMP]
- negative regulation of gene expression [ISO]
- negative regulation of protein phosphorylation [ISO]
- negative regulation of transporter activity [ISO]
- organ morphogenesis [IMP]
- peptidyl-tyrosine autophosphorylation [IDA]
- peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of DNA replication [ISO]
- positive regulation of MAPK cascade [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of developmental growth [ISO]
- positive regulation of glucose import [ISO]
- positive regulation of glycogen biosynthetic process [IMP, ISO]
- positive regulation of glycolytic process [ISO]
- positive regulation of glycoprotein biosynthetic process [ISO]
- positive regulation of mitosis [IMP, ISO]
- positive regulation of nitric oxide biosynthetic process [ISO]
- positive regulation of phosphorylation [ISO]
- positive regulation of protein kinase B signaling [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of respiratory burst [ISO]
- protein autophosphorylation [ISO]
- protein heterotetramerization [ISO]
- protein phosphorylation [ISO]
- regulation of embryonic development [ISO]
- regulation of hydrogen peroxide metabolic process [ISO]
- regulation of transcription, DNA-templated [ISO]
- response to tumor necrosis factor [ISO]
- signal transduction by phosphorylation [ISO]
- transformation of host cell by virus [ISO]
Gene Ontology Molecular Function- 3-phosphoinositide-dependent protein kinase binding [ISO]
- ATP binding [ISO]
- GTP binding [ISO]
- PTB domain binding [ISO]
- insulin binding [ISO]
- insulin receptor substrate binding [ISO]
- insulin-activated receptor activity [ISO]
- insulin-like growth factor I binding [ISO]
- insulin-like growth factor II binding [ISO]
- insulin-like growth factor receptor binding [ISO]
- lipoic acid binding [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein domain specific binding [ISO]
- protein kinase activity [ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
- protein tyrosine kinase activity [ISO]
- receptor signaling protein tyrosine kinase activity [ISO]
- 3-phosphoinositide-dependent protein kinase binding [ISO]
- ATP binding [ISO]
- GTP binding [ISO]
- PTB domain binding [ISO]
- insulin binding [ISO]
- insulin receptor substrate binding [ISO]
- insulin-activated receptor activity [ISO]
- insulin-like growth factor I binding [ISO]
- insulin-like growth factor II binding [ISO]
- insulin-like growth factor receptor binding [ISO]
- lipoic acid binding [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein domain specific binding [ISO]
- protein kinase activity [ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
- protein tyrosine kinase activity [ISO]
- receptor signaling protein tyrosine kinase activity [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
ARRB2
AI326910, AW122872, DN-491F10.4
arrestin, beta 2
GO Process (38)
GO Function (18)
GO Component (10)
Gene Ontology Biological Process
- G-protein coupled receptor internalization [ISO]
- G-protein coupled receptor signaling pathway [ISO]
- adult walking behavior [IMP]
- cell chemotaxis [ISO]
- desensitization of G-protein coupled receptor protein signaling pathway by arrestin [ISO]
- detection of temperature stimulus involved in sensory perception of pain [ISO]
- endocytosis [ISO]
- follicle-stimulating hormone signaling pathway [ISO]
- negative regulation of GTPase activity [ISO]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of interleukin-1 beta production [IMP]
- negative regulation of interleukin-12 production [IMP]
- negative regulation of interleukin-6 production [IMP]
- negative regulation of natural killer cell mediated cytotoxicity [ISO]
- negative regulation of protein ubiquitination [ISO]
- negative regulation of release of cytochrome c from mitochondria [ISO]
- negative regulation of smooth muscle cell apoptotic process [ISO]
- negative regulation of toll-like receptor signaling pathway [IMP]
- negative regulation of tumor necrosis factor production [IMP]
- positive regulation of DNA biosynthetic process [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of calcium ion transport [ISO]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of protein kinase B signaling [IMP, ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of protein ubiquitination [ISO]
- positive regulation of receptor internalization [ISO]
- positive regulation of synaptic transmission, dopaminergic [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO]
- protein ubiquitination [ISO]
- receptor internalization [ISO]
- regulation of G-protein coupled receptor protein signaling pathway [IMP, ISO]
- regulation of androgen receptor signaling pathway [ISO]
- regulation of protein phosphorylation [IDA, IGI]
- transcription from RNA polymerase II promoter [ISO]
- transforming growth factor beta receptor signaling pathway [ISO]
Gene Ontology Molecular Function- 14-3-3 protein binding [ISO]
- D1 dopamine receptor binding [ISO]
- G-protein coupled receptor binding [ISO]
- alpha-1A adrenergic receptor binding [ISO]
- alpha-1B adrenergic receptor binding [ISO]
- angiotensin receptor binding [ISO]
- enzyme binding [ISO]
- follicle-stimulating hormone receptor binding [ISO]
- mitogen-activated protein kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein complex scaffold [ISO]
- protein domain specific binding [ISO]
- protein kinase B binding [IPI]
- receptor binding [ISO]
- type 1 angiotensin receptor binding [ISO]
- type 2A serotonin receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- 14-3-3 protein binding [ISO]
- D1 dopamine receptor binding [ISO]
- G-protein coupled receptor binding [ISO]
- alpha-1A adrenergic receptor binding [ISO]
- alpha-1B adrenergic receptor binding [ISO]
- angiotensin receptor binding [ISO]
- enzyme binding [ISO]
- follicle-stimulating hormone receptor binding [ISO]
- mitogen-activated protein kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein complex scaffold [ISO]
- protein domain specific binding [ISO]
- protein kinase B binding [IPI]
- receptor binding [ISO]
- type 1 angiotensin receptor binding [ISO]
- type 2A serotonin receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance.
Insulin resistance, a hallmark of type 2 diabetes, is a defect of insulin in stimulating insulin receptor signalling, which has become one of the most serious public health threats. Upon stimulation by insulin, insulin receptor recruits and phosphorylates insulin receptor substrate proteins, leading to activation of the phosphatidylinositol-3-OH kinase (PI(3)K)-Akt pathway. Activated Akt phosphorylates downstream kinases and transcription factors, thus ... [more]
Nature Feb. 26, 2009; 457(7233);1146-9 [Pubmed: 19122674]
Throughput
- Low Throughput
Curated By
- BioGRID