BAIT

MUL1

C1orf166, GIDE, MAPL, MULAN, RNF218, RP11-401M16.2
mitochondrial E3 ubiquitin protein ligase 1
Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Mulan E3 ubiquitin ligase interacts with multiple E2 conjugating enzymes and participates in mitophagy by recruiting GABARAP.

Ambivero CT, Cilenti L, Main S, Zervos AS

Mulan is an E3 ubiquitin ligase embedded in the outer mitochondrial membrane (OMM) with its RING finger facing the cytoplasm and a large domain located in the intermembrane space (IMS). Mulan is known to have an important role in cell growth, cell death, and more recently in mitophagy. The mechanism of its function is poorly understood; but as an E3 ... [more]

Cell. Signal. Sep. 16, 2014; 26(12);2921-2929 [Pubmed: 25224329]

Throughput

  • Low Throughput

Curated By

  • BioGRID