BAIT
MUL1
C1orf166, GIDE, MAPL, MULAN, RNF218, RP11-401M16.2
mitochondrial E3 ubiquitin protein ligase 1
GO Process (18)
GO Function (6)
GO Component (6)
Gene Ontology Biological Process
- activation of JUN kinase activity [IDA]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- cellular response to exogenous dsRNA [IDA]
- mitochondrial fission [IMP]
- mitochondrion localization [IMP]
- negative regulation of cell growth [IDA]
- negative regulation of chemokine (C-C motif) ligand 5 production [IMP]
- negative regulation of defense response to virus by host [IMP]
- negative regulation of innate immune response [IMP]
- negative regulation of mitochondrial fusion [IDA]
- negative regulation of protein kinase B signaling [IDA]
- negative regulation of type I interferon-mediated signaling pathway [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of mitochondrial fission [IDA]
- positive regulation of protein sumoylation [IDA]
- protein stabilization [IMP]
- protein ubiquitination [IDA]
- regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
UBE2E2
UBCH8
ubiquitin-conjugating enzyme E2E 2
GO Process (6)
GO Function (4)
GO Component (0)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Mulan E3 ubiquitin ligase interacts with multiple E2 conjugating enzymes and participates in mitophagy by recruiting GABARAP.
Mulan is an E3 ubiquitin ligase embedded in the outer mitochondrial membrane (OMM) with its RING finger facing the cytoplasm and a large domain located in the intermembrane space (IMS). Mulan is known to have an important role in cell growth, cell death, and more recently in mitophagy. The mechanism of its function is poorly understood; but as an E3 ... [more]
Cell. Signal. Sep. 16, 2014; 26(12);2921-2929 [Pubmed: 25224329]
Throughput
- Low Throughput
Curated By
- BioGRID