A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Publication

A systematic genetic screen identifies new factors influencing centromeric heterochromatin integrity in fission yeast.

Bayne EH, Bijos DA, White SA, de Lima Alves F, Rappsilber J, Allshire RC

BackgroundHeterochromatin plays important roles in the regulation and stability of eukaryotic genomes. Both heterochromatin components and pathways that promote heterochromatin assembly, including RNA interference, RNAi, are broadly conserved between the fission yeast Schizosaccharomyces pombe and humans. As a result, fission yeast has emerged as an important model system for dissecting mechanisms governing heterochromatin integrity. Thus far, over 50 proteins have ... [more]

Genome Biol. Oct. 02, 2014; 15(10);481 [Pubmed: 25274039]

Throughput

Low Throughput

Ontology Terms

phenotype: vegetative growth (APO:0000106)

Additional Notes

Figure 4

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
SAF1 CWF11	Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.	Ren L (2011)	High	-	BioGRID	-
SAF1 CWF11	Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.	Ren L (2011)	Low	-	BioGRID	518710

Curated By

BioGRID

Interaction Summary

CWF11

Gene Ontology Biological Process

Gene Ontology Cellular Component

SAF1