Phenotypic Suppression

A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

A systematic genetic screen identifies new factors influencing centromeric heterochromatin integrity in fission yeast.

Bayne EH, Bijos DA, White SA, de Lima Alves F, Rappsilber J, Allshire RC

BackgroundHeterochromatin plays important roles in the regulation and stability of eukaryotic genomes. Both heterochromatin components and pathways that promote heterochromatin assembly, including RNA interference, RNAi, are broadly conserved between the fission yeast Schizosaccharomyces pombe and humans. As a result, fission yeast has emerged as an important model system for dissecting mechanisms governing heterochromatin integrity. Thus far, over 50 proteins have ... [more]

Genome Biol. Oct. 02, 2014; 15(10);481 [Pubmed: 25274039]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: silencing (APO:0000046)

Additional Notes

  • Figure 6
  • epe1 deletion restores silencing in ddb1 mutant
  • spd1 null background

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
DDB1 EPE1
Negative Genetic
Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

High-7.1478BioGRID
527672
DDB1 EPE1
Negative Genetic
Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

High-3.2981BioGRID
784641
EPE1 DDB1
Negative Genetic
Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

High-3.2981BioGRID
788465
DDB1 EPE1
Phenotypic Suppression
Phenotypic Suppression

A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Low-BioGRID
487328

Curated By

  • BioGRID