A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

A systematic genetic screen identifies new factors influencing centromeric heterochromatin integrity in fission yeast.

Bayne EH, Bijos DA, White SA, de Lima Alves F, Rappsilber J, Allshire RC

BackgroundHeterochromatin plays important roles in the regulation and stability of eukaryotic genomes. Both heterochromatin components and pathways that promote heterochromatin assembly, including RNA interference, RNAi, are broadly conserved between the fission yeast Schizosaccharomyces pombe and humans. As a result, fission yeast has emerged as an important model system for dissecting mechanisms governing heterochromatin integrity. Thus far, over 50 proteins have ... [more]

Genome Biol. Oct. 02, 2014; 15(10);481 [Pubmed: 25274039]

Throughput

Low Throughput

Ontology Terms

phenotype: silencing (APO:0000046)

Additional Notes

Figure 6
epe1 deletion restores silencing in csn2 mutant
spd1 null background

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
CSN2 EPE1	Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.	Ryan CJ (2012)	High	-3	BioGRID	761495

Curated By

BioGRID

Interaction Summary

CSN2

Gene Ontology Biological Process

Gene Ontology Cellular Component

EPE1

Gene Ontology Biological Process

Gene Ontology Molecular Function

histone demethylase activity (H3-K36 specific) [ISO]protein binding [IPI]