TPP1
Gene Ontology Biological Process
- activation of signaling protein activity involved in unfolded protein response [TAS]
- bone resorption [IMP]
- cellular protein metabolic process [TAS]
- endoplasmic reticulum unfolded protein response [TAS]
- epithelial cell differentiation [IEP]
- lipid metabolic process [TAS]
- lysosome organization [ISS]
- nervous system development [IMP]
- neuromuscular process controlling balance [ISS]
- peptide catabolic process [IMP]
- protein catabolic process [NAS]
- proteolysis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TERT
Gene Ontology Biological Process
- DNA strand elongation [IDA]
- age-dependent telomere shortening [IBA]
- mitochondrion organization [IDA]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- positive regulation of Wnt signaling pathway [IGI]
- replicative senescence [IMP]
- telomere formation via telomerase [IDA]
- telomere maintenance [TAS]
- telomere maintenance via telomerase [IMP, NAS, TAS]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA-directed DNA polymerase activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- tRNA binding [IDA]
- telomerase activity [IDA]
- telomeric DNA binding [TAS]
- telomeric RNA binding [IDA]
- telomeric template RNA reverse transcriptase activity [IDA, TAS]
- transcription coactivator binding [IPI]
- DNA binding [IDA]
- RNA-directed DNA polymerase activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- tRNA binding [IDA]
- telomerase activity [IDA]
- telomeric DNA binding [TAS]
- telomeric RNA binding [IDA]
- telomeric template RNA reverse transcriptase activity [IDA, TAS]
- transcription coactivator binding [IPI]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
The Shelterin Component TPP1 Is a Binding Partner and Substrate for the Deubiquitinating Enzyme USP7.
The telomeric shelterin component TPP1 has critical functions in telomeric protein complex assembly and telomerase recruitment and regulation. Here we identify USP7 as a novel interacting protein of the oligonucleotide/oligosaccharide-binding fold of TPP1, which was previously known to recruit telomerase to telomeres. We identify amino acids in TPP1 and USP7 that are critical for their interaction and multiple lysines within ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TPP1 TERT | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID