HUWE1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RTN4
Gene Ontology Biological Process
- apoptotic process [NAS]
- axonal fasciculation [IBA, ISS]
- cerebral cortex radial glia guided migration [ISS]
- endoplasmic reticulum tubular network organization [IMP]
- negative regulation of axon extension [IDA]
- negative regulation of axonogenesis [TAS]
- negative regulation of cell growth [IMP]
- neurotrophin TRK receptor signaling pathway [TAS]
- regulation of apoptotic process [NAS]
- regulation of axonogenesis [TAS]
- regulation of branching morphogenesis of a nerve [ISS]
- regulation of cell migration [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Quantitative diGly Proteomics Coupled with Inducible RNAi Reveals Ubiquitin-Mediated Proteolysis of DDIT4 by the E3 Ligase HUWE1.
Targeted degradation of proteins through the ubiquitin-proteasome system (UPS) via the activities of E3 ubiquitin ligases regulates diverse cellular processes, and misregulation of these enzymes contributes to the pathogenesis of human diseases. One of the challenges facing the UPS field is to delineate the complete cohort of substrates for a particular E3 ligase. Advances in mass spectrometry and the development ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HUWE1 RTN4 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - |
Curated By
- BioGRID