PREY
PLCE1
NPHS3, PLCE, PPLC, RP11-76P2.1
phospholipase C, epsilon 1
GO Process (22)
GO Function (7)
GO Component (3)
Gene Ontology Biological Process
- Ras protein signal transduction [TAS]
- activation of MAPK activity [IDA]
- calcium-mediated signaling [NAS, TAS]
- cell proliferation [NAS]
- cytoskeleton organization [NAS]
- diacylglycerol biosynthetic process [TAS]
- epidermal growth factor receptor signaling pathway [NAS]
- glomerulus development [IMP]
- heart development [TAS]
- inositol phosphate metabolic process [TAS]
- inositol phosphate-mediated signaling [TAS]
- phospholipase C-activating G-protein coupled receptor signaling pathway [IDA]
- phospholipid metabolic process [IC]
- positive regulation of GTPase activity [TAS]
- positive regulation of cytosolic calcium ion concentration [TAS]
- protein kinase C-activating G-protein coupled receptor signaling pathway [NAS]
- regulation of G-protein coupled receptor protein signaling pathway [IDA]
- regulation of Ras protein signal transduction [IDA]
- regulation of cell growth [TAS]
- regulation of protein kinase activity [IDA]
- regulation of smooth muscle contraction [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways.
Fused-in-sarcoma (FUS) is a nuclear protein linked to amyotrophic lateral sclerosis and frontotemporal dementia. Under pathologic conditions, FUS frequently is accumulated in cytosoplasm, but how this altered distribution affects the protein interaction pattern of FUS is unclear. Using dual-tag affinity purification and mass spectrometry, we compared the interactome of the wild-type FUS and the P525Â L mutant, which causes juvenile amyotrophic ... [more]
Neurobiol. Aging Aug. 04, 2014; 0(0); [Pubmed: 25192599]
Throughput
- High Throughput
Curated By
- BioGRID