BAIT

FUS

ALS6, ETM4, FUS1, HNRNPP2, POMP75, TLS

FUS RNA binding protein

GO Process (3)

GO Function (4)

GO Component (2)

Gene Ontology Biological Process

RNA splicing [TAS]

gene expression [TAS]

mRNA splicing, via spliceosome [TAS]

Gene Ontology Molecular Function

RNA binding [TAS]
identical protein binding [IPI]
poly(A) RNA binding [IDA]
protein binding [IPI]

Gene Ontology Cellular Component

nucleoplasm [IDA, TAS]

CRISPR Database VEGA OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

DNAJC10

ERdj5, JPDI, MTHr, PDIA19, UNQ495/PRO1012

DnaJ (Hsp40) homolog, subfamily C, member 10

GO Process (6)

GO Function (9)

GO Component (4)

Gene Ontology Biological Process

ER-associated ubiquitin-dependent protein catabolic process [IMP]

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [IDA]

negative regulation of protein phosphorylation [IDA]

positive regulation of ATPase activity [ISS]

protein folding in endoplasmic reticulum [IDA]

response to endoplasmic reticulum stress [IDA]

Gene Ontology Molecular Function

ATPase activator activity [ISS]
ATPase binding [IPI]
Hsp70 protein binding [IPI]
chaperone binding [IDA]
disulfide oxidoreductase activity [ISS]
misfolded protein binding [IDA]
oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [ISS]
protein binding [IPI]
protein disulfide oxidoreductase activity [IDA, ISS]

Gene Ontology Cellular Component

endoplasmic reticulum [IDA]

endoplasmic reticulum chaperone complex [IDA]

endoplasmic reticulum lumen [IDA]

CRISPR Database HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways.

Wang T, Jiang X, Chen G, Xu J

Fused-in-sarcoma (FUS) is a nuclear protein linked to amyotrophic lateral sclerosis and frontotemporal dementia. Under pathologic conditions, FUS frequently is accumulated in cytosoplasm, but how this altered distribution affects the protein interaction pattern of FUS is unclear. Using dual-tag affinity purification and mass spectrometry, we compared the interactome of the wild-type FUS and the P525Â L mutant, which causes juvenile amyotrophic ... [more]

Neurobiol. Aging Aug. 04, 2014; 0(0); [Pubmed: 25192599]

Throughput

High Throughput

Curated By

BioGRID