PREY
UFL1
KIAA0776, Maxer, NLBP, RCAD, RP3-393D12.1
UFM1-specific ligase 1
GO Process (6)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- negative regulation of NF-kappaB transcription factor activity [IMP]
- negative regulation of protein ubiquitination [IDA]
- osteoblast differentiation [IDA]
- protein ufmylation [IDA, IMP]
- regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- response to endoplasmic reticulum stress [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways.
Fused-in-sarcoma (FUS) is a nuclear protein linked to amyotrophic lateral sclerosis and frontotemporal dementia. Under pathologic conditions, FUS frequently is accumulated in cytosoplasm, but how this altered distribution affects the protein interaction pattern of FUS is unclear. Using dual-tag affinity purification and mass spectrometry, we compared the interactome of the wild-type FUS and the P525Â L mutant, which causes juvenile amyotrophic ... [more]
Neurobiol. Aging Aug. 04, 2014; 0(0); [Pubmed: 25192599]
Throughput
- High Throughput
Additional Notes
- P525 L mutant
Curated By
- BioGRID