A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Increased Meiotic Crossovers and Reduced Genome Stability in Absence of Schizosaccharomyces pombe Rad16 (XPF).

Mastro TL, Forsburg SL

Schizosaccharomyces pombe Rad16 is the orthologue of the XPF structure-specific endonuclease, which is required for nucleotide excision repair and implicated in the single strand annealing mechanism of recombination. We show that Rad16 is important for proper completion of meiosis. In its absence, cells suffer reduced spore viability and abnormal chromosome segregation with evidence for fragmentation. Recombination between homologous chromosomes is ... [more]

Genetics Oct. 06, 2014; 0(0); [Pubmed: 25293972]

Throughput

Low Throughput

Ontology Terms

phenotype: inviable (APO:0000112)

Additional Notes

Table 1
rad16-249 allele

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
RAD16 RAD3	Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.	Noguchi C (2017)	Low	-	PomBase	-

Curated By

BioGRID

Interaction Summary

RAD16

Gene Ontology Biological Process

Gene Ontology Molecular Function

DNA binding [ISO]single-stranded DNA endodeoxyribonuclease activity [ISS]

Gene Ontology Cellular Component

RAD3