A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Increased Meiotic Crossovers and Reduced Genome Stability in Absence of Schizosaccharomyces pombe Rad16 (XPF).

Mastro TL, Forsburg SL

Schizosaccharomyces pombe Rad16 is the orthologue of the XPF structure-specific endonuclease, which is required for nucleotide excision repair and implicated in the single strand annealing mechanism of recombination. We show that Rad16 is important for proper completion of meiosis. In its absence, cells suffer reduced spore viability and abnormal chromosome segregation with evidence for fragmentation. Recombination between homologous chromosomes is ... [more]

Genetics Oct. 06, 2014; 0(0); [Pubmed: 25293972]

Throughput

Low Throughput

Ontology Terms

phenotype: inviable (APO:0000112)

Additional Notes

Table 1
rad16-249 pcn1-K164R

Curated By

BioGRID

Interaction Summary

RAD16

Gene Ontology Biological Process

Gene Ontology Molecular Function

DNA binding [ISO]single-stranded DNA endodeoxyribonuclease activity [ISS]

Gene Ontology Cellular Component

PCN1

Gene Ontology Biological Process

Gene Ontology Molecular Function

DNA polymerase processivity factor activity [ISS]protein binding [IPI]