BAIT
AKT1
Akt
v-akt murine thymoma viral oncogene homolog 1
GO Process (81)
GO Function (15)
GO Component (11)
Gene Ontology Biological Process
- activation-induced cell death of T cells [ISO]
- aging [IDA]
- apoptotic mitochondrial changes [ISO]
- cell projection organization [IDA]
- cellular response to epidermal growth factor stimulus [ISO]
- cellular response to granulocyte macrophage colony-stimulating factor stimulus [ISO]
- cellular response to growth factor stimulus [ISO]
- cellular response to hypoxia [IDA]
- cellular response to insulin stimulus [IMP, ISO]
- cellular response to mechanical stimulus [IDA]
- cellular response to organic cyclic compound [IDA]
- cellular response to peptide [ISO]
- execution phase of apoptosis [ISO]
- germ cell development [ISO]
- glucose homeostasis [ISO]
- glucose metabolic process [ISO]
- glucose transport [ISO]
- glycogen biosynthetic process [IMP]
- glycogen cell differentiation involved in embryonic placenta development [ISO]
- glycogen metabolic process [ISO]
- hyaluronan metabolic process [IEP]
- inflammatory response [ISO]
- insulin receptor signaling pathway [IMP, ISO, ISS]
- insulin-like growth factor receptor signaling pathway [ISO, ISS]
- intracellular signal transduction [ISO]
- labyrinthine layer blood vessel development [ISO]
- maternal placenta development [ISO]
- negative regulation of JNK cascade [IDA]
- negative regulation of apoptotic process [ISO, TAS]
- negative regulation of autophagy [ISO]
- negative regulation of cell size [IDA]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO, ISS]
- negative regulation of endopeptidase activity [ISO]
- negative regulation of fatty acid beta-oxidation [ISO]
- negative regulation of plasma membrane long-chain fatty acid transport [ISO]
- negative regulation of protein kinase activity [IDA, ISO]
- negative regulation of proteolysis [ISO]
- negative regulation of release of cytochrome c from mitochondria [ISO, ISS]
- osteoblast differentiation [ISO]
- peptidyl-serine phosphorylation [IDA, ISO]
- peripheral nervous system myelin maintenance [ISO]
- phosphorylation [ISO, ISS]
- positive regulation of apoptotic process [IMP]
- positive regulation of blood vessel endothelial cell migration [ISO]
- positive regulation of cell growth [IDA, ISO]
- positive regulation of cellular protein metabolic process [IMP]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [ISO]
- positive regulation of endothelial cell proliferation [ISO, ISS]
- positive regulation of establishment of protein localization to plasma membrane [ISO]
- positive regulation of fat cell differentiation [ISO]
- positive regulation of glucose import [ISO]
- positive regulation of glucose metabolic process [ISO]
- positive regulation of glycogen biosynthetic process [ISO]
- positive regulation of lipid biosynthetic process [ISO]
- positive regulation of nitric oxide biosynthetic process [ISO]
- positive regulation of nitric-oxide synthase activity [ISO]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of sodium ion transport [IMP, ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of vasoconstriction [IMP]
- protein catabolic process [ISO]
- protein import into nucleus, translocation [ISO]
- protein kinase B signaling [ISO]
- protein phosphorylation [IDA, ISO, ISS]
- protein ubiquitination [ISO]
- regulation of cell migration [IMP, ISO]
- regulation of glycogen biosynthetic process [ISO]
- regulation of myelination [ISO]
- regulation of neuron projection development [ISO, ISS]
- regulation of protein localization [IMP, ISO]
- response to UV-A [ISO]
- response to fluid shear stress [ISO]
- response to food [ISO]
- response to hormone [ISO]
- response to oxidative stress [ISS]
- signal transduction [IDA]
- striated muscle cell differentiation [ISO]
- translation [IMP]
Gene Ontology Molecular Function- 14-3-3 protein binding [ISO]
- ATP binding [IDA, ISO]
- enzyme binding [IPI]
- identical protein binding [ISO]
- kinase activity [ISO]
- nitric-oxide synthase regulator activity [ISO]
- phosphatidylinositol-3,4,5-trisphosphate binding [ISO]
- phosphatidylinositol-3,4-bisphosphate binding [ISO]
- protein binding [IPI]
- protein kinase C binding [IPI]
- protein kinase activity [IDA, ISO]
- protein kinase binding [ISO]
- protein phosphatase 2A binding [IPI]
- protein serine/threonine kinase activity [IDA, ISO, ISS, TAS]
- protein serine/threonine/tyrosine kinase activity [ISO]
- 14-3-3 protein binding [ISO]
- ATP binding [IDA, ISO]
- enzyme binding [IPI]
- identical protein binding [ISO]
- kinase activity [ISO]
- nitric-oxide synthase regulator activity [ISO]
- phosphatidylinositol-3,4,5-trisphosphate binding [ISO]
- phosphatidylinositol-3,4-bisphosphate binding [ISO]
- protein binding [IPI]
- protein kinase C binding [IPI]
- protein kinase activity [IDA, ISO]
- protein kinase binding [ISO]
- protein phosphatase 2A binding [IPI]
- protein serine/threonine kinase activity [IDA, ISO, ISS, TAS]
- protein serine/threonine/tyrosine kinase activity [ISO]
Gene Ontology Cellular Component
Rattus norvegicus
PREY
GSK3B
glycogen synthase kinase 3 beta
GO Process (56)
GO Function (17)
GO Component (19)
Gene Ontology Biological Process
- ER overload response [ISO]
- Wnt signaling pathway [ISO]
- axonogenesis [ISO]
- canonical Wnt signaling pathway [ISO]
- canonical Wnt signaling pathway involved in positive regulation of apoptotic process [ISO]
- cell migration [ISO]
- cellular response to interleukin-3 [ISO, ISS]
- cellular response to mechanical stimulus [IDA]
- circadian rhythm [ISO, ISS]
- epithelial to mesenchymal transition [ISO, ISS]
- establishment of cell polarity [IDA]
- establishment or maintenance of cell polarity [IDA]
- extrinsic apoptotic signaling pathway in absence of ligand [ISO, ISS]
- fat cell differentiation [ISO]
- glycogen metabolic process [ISO]
- hippocampus development [ISO]
- hypermethylation of CpG island [ISO]
- intracellular signal transduction [ISO]
- myoblast fusion [ISO]
- myotube differentiation [ISO]
- negative regulation of MAP kinase activity [IMP]
- negative regulation of NFAT protein import into nucleus [ISO, ISS]
- negative regulation of apoptotic process [ISO]
- negative regulation of cardiac muscle hypertrophy [ISO]
- negative regulation of dendrite morphogenesis [IMP]
- negative regulation of neuron maturation [ISO]
- negative regulation of neuron projection development [ISO]
- negative regulation of protein binding [ISO]
- negative regulation of protein complex assembly [ISO]
- organ morphogenesis [ISO]
- peptidyl-serine phosphorylation [ISO, ISS]
- phosphorylation [ISO]
- positive regulation of Rac GTPase activity [ISO]
- positive regulation of apoptotic process [IDA, IMP]
- positive regulation of axon extension [ISO]
- positive regulation of cell-matrix adhesion [ISO]
- positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [ISO, ISS]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of peptidyl-threonine phosphorylation [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein binding [ISO, ISS]
- positive regulation of protein complex assembly [ISO]
- positive regulation of protein export from nucleus [ISO]
- positive regulation of stem cell differentiation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- protein export from nucleus [ISO]
- protein localization to microtubule [ISO]
- protein phosphorylation [IDA, ISO]
- re-entry into mitotic cell cycle [ISO]
- regulation of gene expression by genetic imprinting [ISO]
- regulation of microtubule-based process [ISO, ISS]
- regulation of neuron projection development [ISO]
- regulation of neuronal synaptic plasticity [IMP]
- response to drug [IEP]
- response to lithium ion [IEP]
- superior temporal gyrus development [ISO]
Gene Ontology Molecular Function- ATP binding [IDA]
- NF-kappaB binding [ISO]
- RNA polymerase II transcription factor binding [ISO]
- beta-catenin binding [ISO]
- integrin binding [IPI]
- ionotropic glutamate receptor binding [IPI]
- kinase activity [ISO, ISS]
- p53 binding [ISO]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [ISO]
- protein kinase activity [ISO]
- protein kinase binding [IPI, ISO]
- protein serine/threonine kinase activity [IDA, ISO, TAS]
- tau protein binding [IDA]
- tau-protein kinase activity [IDA, ISO]
- transcription factor binding [IPI]
- ubiquitin protein ligase binding [ISO]
- ATP binding [IDA]
- NF-kappaB binding [ISO]
- RNA polymerase II transcription factor binding [ISO]
- beta-catenin binding [ISO]
- integrin binding [IPI]
- ionotropic glutamate receptor binding [IPI]
- kinase activity [ISO, ISS]
- p53 binding [ISO]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [ISO]
- protein kinase activity [ISO]
- protein kinase binding [IPI, ISO]
- protein serine/threonine kinase activity [IDA, ISO, TAS]
- tau protein binding [IDA]
- tau-protein kinase activity [IDA, ISO]
- transcription factor binding [IPI]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- beta-catenin destruction complex [IDA, ISO]
- cell body [ISO]
- centrosome [ISO]
- cytoplasm [IDA, ISO, ISS, TAS]
- cytosol [IDA, ISO, TAS]
- dendritic shaft [ISO]
- dendritic spine [IDA]
- growth cone [ISO]
- membrane [IDA]
- membrane raft [IDA]
- membrane-bounded organelle [ISO]
- neuronal cell body [ISO]
- neuronal postsynaptic density [ISO]
- nucleoplasm [ISO]
- nucleus [IDA, ISO, ISS]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [ISO]
- protein complex [IDA]
- ribonucleoprotein complex [ISO]
Rattus norvegicus
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension.
Nitric oxide (NO) production by endothelial cell nitric oxide synthase (eNOS) in sinusoidal endothelial cells is reduced in the injured liver and leads to intrahepatic portal hypertension. We sought to understand the mechanism underlying defective eNOS function. Phosphorylation of the serine-threonine kinase Akt, which activates eNOS, was substantially reduced in sinusoidal endothelial cells from injured livers. Overexpression of Akt in ... [more]
Nat. Med. Sep. 01, 2005; 11(9);952-8 [Pubmed: 16142243]
Throughput
- Low Throughput
Additional Notes
- Akt activity reduced in the presence of GRK2
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| AKT1 GSK3B | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 2600131 | |
| AKT1 GSK3B | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 919301 |
Curated By
- BioGRID