BAIT
KCNMA1
5730414M22Rik, BKCa, MaxiK, Slo, Slo1, mSlo, mSlo1, RP24-486D21.1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
GO Process (33)
GO Function (8)
GO Component (17)
Gene Ontology Biological Process
- adult walking behavior [IMP]
- auditory receptor cell differentiation [IMP]
- cell maturation [IMP]
- cellular potassium ion homeostasis [ISO]
- circadian rhythm [IMP]
- eye blink reflex [IMP]
- locomotor rhythm [IMP]
- micturition [IMP, ISO]
- negative regulation of cell volume [IMP, ISO]
- neuromuscular process controlling balance [IMP]
- neuronal action potential [IMP]
- positive regulation of apoptotic process [ISO]
- potassium ion transmembrane transport [IBA, IGI, ISO]
- potassium ion transport [IDA, ISO]
- protein homooligomerization [IDA]
- protein homotetramerization [ISO]
- regulation of aldosterone metabolic process [IMP]
- regulation of ion transmembrane transport [IMP]
- regulation of membrane potential [IDA, IMP, ISO]
- regulation of vasodilation [ISO]
- relaxation of vascular smooth muscle [IMP]
- response to calcium ion [ISO]
- response to carbon monoxide [ISO]
- response to corticosteroid [ISO]
- response to estrogen [ISO]
- response to hypoxia [IDA, ISO]
- response to osmotic stress [ISO]
- response to pH [ISO]
- saliva secretion [IGI]
- sensory perception of sound [IMP]
- smooth muscle contraction involved in micturition [IMP, ISO]
- synaptic transmission [IMP]
- vasodilation [IMP]
Gene Ontology Molecular Function- actin binding [ISO]
- calcium-activated potassium channel activity [IDA, IGI, IMP, ISO]
- large conductance calcium-activated potassium channel activity [IDA, IMP, ISO]
- potassium channel activity [IGI, IMP]
- protein binding [IPI]
- protein complex binding [ISO]
- protein homodimerization activity [ISO]
- voltage-gated potassium channel activity [IDA, IMP, ISO]
- actin binding [ISO]
- calcium-activated potassium channel activity [IDA, IGI, IMP, ISO]
- large conductance calcium-activated potassium channel activity [IDA, IMP, ISO]
- potassium channel activity [IGI, IMP]
- protein binding [IPI]
- protein complex binding [ISO]
- protein homodimerization activity [ISO]
- voltage-gated potassium channel activity [IDA, IMP, ISO]
Gene Ontology Cellular Component
- apical plasma membrane [IDA, ISO]
- caveola [ISO]
- cell [IMP]
- cytoplasm [IDA]
- dendrite [ISO]
- endoplasmic reticulum [IDA]
- external side of plasma membrane [IDA, ISO]
- extracellular vesicular exosome [ISO]
- integral component of membrane [IC, IDA, ISO]
- neuronal cell body [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- postsynaptic membrane [IDA]
- presynaptic active zone membrane [ISO]
- protein complex [ISO]
- terminal bouton [IDA]
- voltage-gated potassium channel complex [IGI, ISO]
Mus musculus
PREY
APOE
AI255918
apolipoprotein E
GO Process (84)
GO Function (19)
GO Component (28)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISO]
- N-methyl-D-aspartate receptor clustering [ISO]
- aging [ISO]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering [ISO]
- artery morphogenesis [IGI]
- axon regeneration [IGI]
- cGMP-mediated signaling [ISO]
- cardiovascular system development [IMP]
- cellular calcium ion homeostasis [IDA]
- cholesterol biosynthetic process [IBA]
- cholesterol catabolic process [IMP]
- cholesterol efflux [IDA, IMP, ISO]
- cholesterol homeostasis [IGI, IMP, ISO]
- cholesterol metabolic process [IMP, ISO]
- chylomicron remnant clearance [ISO]
- fatty acid homeostasis [ISO]
- high-density lipoprotein particle assembly [IBA, ISO]
- high-density lipoprotein particle clearance [ISO]
- high-density lipoprotein particle remodeling [ISO]
- lipid homeostasis [IMP]
- lipid metabolic process [IGI]
- lipid transport [ISO]
- lipoprotein biosynthetic process [IGI]
- lipoprotein catabolic process [IMP]
- lipoprotein metabolic process [IGI, IMP, ISO]
- long-chain fatty acid transport [ISO]
- low-density lipoprotein particle remodeling [IMP]
- maintenance of location in cell [IMP]
- negative regulation of MAP kinase activity [ISO]
- negative regulation of beta-amyloid formation [ISO]
- negative regulation of blood coagulation [ISO]
- negative regulation of blood vessel endothelial cell migration [ISO]
- negative regulation of cholesterol biosynthetic process [ISO]
- negative regulation of cholesterol efflux [ISO]
- negative regulation of dendritic spine development [ISO]
- negative regulation of dendritic spine maintenance [ISO]
- negative regulation of endothelial cell proliferation [ISO]
- negative regulation of inflammatory response [IGI]
- negative regulation of lipid biosynthetic process [ISO]
- negative regulation of lipid transport across blood brain barrier [ISO]
- negative regulation of neuron apoptotic process [IBA, ISO]
- negative regulation of neuron death [ISO]
- negative regulation of phospholipid efflux [ISO]
- negative regulation of platelet activation [ISO]
- negative regulation of postsynaptic membrane organization [ISO]
- negative regulation of presynaptic membrane organization [ISO]
- nitric oxide mediated signal transduction [ISO]
- phospholipid efflux [IBA, ISO]
- positive regulation of axon extension [ISO]
- positive regulation of beta-amyloid formation [ISO]
- positive regulation of cGMP biosynthetic process [ISO]
- positive regulation of catalytic activity [IMP]
- positive regulation of cholesterol efflux [ISO]
- positive regulation of cholesterol esterification [IMP, ISO]
- positive regulation of dendritic spine development [ISO]
- positive regulation of dendritic spine maintenance [ISO]
- positive regulation of lipid biosynthetic process [IBA, ISO]
- positive regulation of lipid transport across blood brain barrier [ISO]
- positive regulation of low-density lipoprotein particle receptor catabolic process [ISO]
- positive regulation of membrane protein ectodomain proteolysis [ISO]
- positive regulation of neurofibrillary tangle assembly [ISO]
- positive regulation of neuron death [ISO]
- positive regulation of nitric-oxide synthase activity [IBA, ISO]
- positive regulation of phospholipid efflux [ISO]
- positive regulation of postsynaptic membrane organization [ISO]
- positive regulation of presynaptic membrane organization [ISO]
- protein import [ISO]
- protein localization [IMP]
- receptor-mediated endocytosis [ISO]
- regulation of Cdc42 protein signal transduction [ISO]
- regulation of axon extension [IBA]
- regulation of beta-amyloid clearance [IBA, ISO]
- regulation of cholesterol transport [IBA]
- regulation of gene expression [IMP]
- regulation of neuron death [ISO]
- regulation of tau-protein kinase activity [ISO]
- response to dietary excess [IMP]
- response to oxidative stress [IMP]
- reverse cholesterol transport [IBA, ISO]
- triglyceride catabolic process [IBA]
- triglyceride metabolic process [ISO]
- vasodilation [IMP]
- very-low-density lipoprotein particle clearance [ISO]
- very-low-density lipoprotein particle remodeling [IMP, ISO]
Gene Ontology Molecular Function- antioxidant activity [ISO]
- beta-amyloid binding [IBA, ISO]
- cholesterol binding [IBA]
- cholesterol transporter activity [IDA]
- heparin binding [ISO]
- hydroxyapatite binding [ISO]
- identical protein binding [ISO]
- lipid binding [ISO]
- lipid transporter activity [ISO]
- lipoprotein particle binding [IDA]
- low-density lipoprotein particle receptor binding [IBA, ISO]
- metal chelating activity [ISO]
- phosphatidylcholine-sterol O-acyltransferase activator activity [IMP, ISO]
- phospholipid binding [IBA, ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- receptor binding [ISO]
- tau protein binding [ISO]
- very-low-density lipoprotein particle receptor binding [IBA, ISO]
- antioxidant activity [ISO]
- beta-amyloid binding [IBA, ISO]
- cholesterol binding [IBA]
- cholesterol transporter activity [IDA]
- heparin binding [ISO]
- hydroxyapatite binding [ISO]
- identical protein binding [ISO]
- lipid binding [ISO]
- lipid transporter activity [ISO]
- lipoprotein particle binding [IDA]
- low-density lipoprotein particle receptor binding [IBA, ISO]
- metal chelating activity [ISO]
- phosphatidylcholine-sterol O-acyltransferase activator activity [IMP, ISO]
- phospholipid binding [IBA, ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- receptor binding [ISO]
- tau protein binding [ISO]
- very-low-density lipoprotein particle receptor binding [IBA, ISO]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- blood microparticle [IBA, ISO]
- cell [IDA]
- cell surface [ISO]
- chylomicron [IBA, ISO]
- cytoplasm [ISO]
- dendrite [ISO]
- discoidal high-density lipoprotein particle [ISO]
- early endosome [ISO]
- endoplasmic reticulum [ISO]
- endosome [ISO]
- extracellular matrix [ISO]
- extracellular space [IDA, ISO]
- extracellular vesicular exosome [ISO]
- extrinsic component of external side of plasma membrane [ISO]
- high-density lipoprotein particle [IBA, ISO]
- intermediate-density lipoprotein particle [IBA, ISO]
- late endosome [ISO]
- low-density lipoprotein particle [IDA, ISO]
- lysosome [ISO]
- membrane [ISO]
- microtubule [ISO]
- neuronal cell body [ISO]
- nuclear envelope [ISO]
- nucleus [ISO]
- plasma membrane [ISO]
- very-low-density lipoprotein particle [ISO]
- vesicle [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A protein interaction network for the large conductance Ca(2+)-activated K(+) channel in the mouse cochlea.
The large conductance Ca(2+)-activated K(+) or BK channel has a role in sensory/neuronal excitation, intracellular signaling, and metabolism. In the non-mammalian cochlea, the onset of BK during development correlates with increased hearing sensitivity and underlies frequency tuning in non-mammals, whereas its role is less clear in mammalian hearing. To gain insights into BK function in mammals, coimmunoprecipitation and two-dimensional PAGE, ... [more]
Mol. Cell Proteomics Aug. 01, 2009; 8(8);1972-87 [Pubmed: 19423573]
Throughput
- Low Throughput
Curated By
- BioGRID